2. Gene
  3. S1pr5 - sphingosine-1-phosphate receptor 5 Gene

S1pr5 - sphingosine-1-phosphate receptor 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Edg8; Edg-8

Gene ID: 60399 | Gene type: protein coding

About S1pr5

Primary_assembly 8: 19,786,663-19,791,795 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 236 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in Brain (RPKM 55.), Lung (RPKM 18.2) and 4 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Is integral component of membrane. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

S1pr5 Products(1)

mRNA Protein Name
NM_021775.2 NP_068543.2 sphingosine 1-phosphate receptor 5

S1pr5 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (36 - 317)

7tm_GPCRs

7tm_GPCRs: cd14964 (38 - 62)

7tm_GPCRs

7tm_GPCRs: cd14964 (71 - 92)

7tm_GPCRs

7tm_GPCRs: cd14964 (108 - 130)

7tm_GPCRs

7tm_GPCRs: cd14964 (152 - 168)

7tm_GPCRs

7tm_GPCRs: cd14964 (189 - 212)

7tm_GPCRs

7tm_GPCRs: cd14964 (250 - 272)

7tm_GPCRs

7tm_GPCRs: cd14964 (285 - 310)

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Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 5

NRG-1

S1P receptor 5

S1P receptor Edg-8

S1P5

endothelial differentiation G-protein-coupled receptor 8

endothelial differentiation, sphingolipid G-protein-coupled receptor, 8

nerve growth factor-regulated G-protein-coupled receptor 1

sphingosine 1-phosphate receptor Edg-8

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 98.88% Yes
HY-12288 Ozanimod Agonist 99.88% Yes
HY-10569 Ponesimod Agonist 99.81% Yes
HY-12288A Ozanimod hydrochloride Modulator 99.19% Yes
HY-12355A Siponimod hemifumarate Agonist / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136578 RP101988 Agonist 98.92% Unkown
HY-111253 CYM-5478 Agonist / Unkown
HY-148198 S1P5 receptor agonist-1 Agonist / Unkown
HY-136576 RP101075 Agonist / Unkown
HY-148115 S1p receptor agonist 2 Agonist / Unkown
HY-136577 RP101442 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr5 NCBI NCBI:53637