S1pr5 - sphingosine-1-phosphate receptor 5 Gene

Also Known as Edg8; Edg-8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60399

About S1pr5

Primary_assembly 8: 19,786,663-19,791,795 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 236 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in Brain (RPKM 55.), Lung (RPKM 18.2) and 4 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Is integral component of membrane. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

S1pr5 Products (1)

mRNA Protein Name
NM_021775.2 NP_068543.2 sphingosine 1-phosphate receptor 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
10799507 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of neuron differentiation IEP
IEP: Inferred from expression pattern
12617946 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr5 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (36 - 317)

7tm_GPCRs

7tm_GPCRs: cd14964 (38 - 62)

7tm_GPCRs

7tm_GPCRs: cd14964 (71 - 92)

7tm_GPCRs

7tm_GPCRs: cd14964 (108 - 130)

7tm_GPCRs

7tm_GPCRs: cd14964 (152 - 168)

7tm_GPCRs

7tm_GPCRs: cd14964 (189 - 212)

7tm_GPCRs

7tm_GPCRs: cd14964 (250 - 272)

7tm_GPCRs

7tm_GPCRs: cd14964 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 5

  • NRG-1

  • S1P receptor 5

  • S1P receptor Edg-8

  • S1P5

  • endothelial differentiation G-protein-coupled receptor 8

  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8

  • nerve growth factor-regulated G-protein-coupled receptor 1

  • sphingosine 1-phosphate receptor Edg-8

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-12288 Ozanimod Agonist 99.98% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12288A Ozanimod hydrochloride Modulator 98.10% Yes
HY-12355A Siponimod hemifumarate Agonist 99.64% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-136578 RP101988 Agonist 98.80% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-136576 RP101075 Agonist 99.19% Unkown
HY-148115 S1p receptor agonist 2 Agonist / Unkown
HY-148198 S1P5 receptor agonist-1 Agonist / Unkown
HY-136577 RP101442 Agonist / Unkown
HY-14402 AMG 369 Agonist / Unkown
HY-181875 S1PR1/S1PR5 agonist-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr5 NCBI NCBI:53637