S1PR5 - sphingosine-1-phosphate receptor 5 Gene

Also Known as EDG8; S1P5; Edg-8; SPPR-1; SPPR-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53637

About S1PR5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,512,742-10,517,965 (from NCBI)

This gene has 3 transcripts (splice variants), 236 orthologues and 18 paralogues. Biased expression in skin (RPKM 5.9), bone marrow (RPKM 5.0) and 10 other tissues.

Summary

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, Apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; Others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

S1PR5 Products (2)

mRNA Protein Name
NM_001166215.2 NP_001159687.1 sphingosine 1-phosphate receptor 5
NM_030760.5 NP_110387.1 sphingosine 1-phosphate receptor 5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1PR5 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (53 - 306)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 5

  • S1P receptor 5

  • S1P receptor Edg-8

  • endothelial differentiation G-protein-coupled receptor 8

  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8

  • sphingosine 1-phosphate receptor EDG8

  • sphingosine 1-phosphate receptor Edg-8

S1PR5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S1PR5 Q9H228 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
S1PR5 Q9H228 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
S1PR5 Q9H228 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
S1PR5 Q9H228 GJA8 Homo sapiens P48165
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Secondary Progressive Multiple Sclerosis

  • Secondary-Progressive Ms

  • Spms

  • Multiple Sclerosis, Chronic Progressive

  • Chronic Progressive Multiple Sclerosis

  • Multiple Sclerosis, Secondary Progressive
Primary Progressive Multiple Sclerosis

  • Ppms

  • Primary-Progressive Ms

  • Multiple Sclerosis, Primary Progressive
Second-Degree Atrioventricular Block

  • Second-Degree Heart Block

  • Second Degree Atrioventricular Block

  • Second Degree Atrioventricular Heart Block

  • Second Degree Heart Block

  • Incomplete Atrioventricular Block, Second Degree Nos

  • Second-Degree Block, Type 1 And 2

  • Atrioventricular Block, Type 1 And 2

  • Second Degree Incomplete Atrioventricular Block

  • Av - [Atrioventricular] Block 2nd
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-12288 Ozanimod Agonist 99.98% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12288A Ozanimod hydrochloride Modulator 98.10% Yes
HY-12355A Siponimod hemifumarate Agonist 99.64% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-136578 RP101988 Agonist 98.80% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-136576 RP101075 Agonist 99.19% Unkown
HY-148115 S1p receptor agonist 2 Agonist / Unkown
HY-148198 S1P5 receptor agonist-1 Agonist / Unkown
HY-136577 RP101442 Agonist / Unkown
HY-14402 AMG 369 Agonist / Unkown
HY-181875 S1PR1/S1PR5 agonist-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus S1PR5 MGD MGI:2150641
Rattus norvegicus S1PR5 RGD RGD:620566
Canis familiaris S1PR5 VGNC VGNC:45838
Macaca mulatta S1PR5 VGNC VGNC:77015
Bos taurus S1PR5 VGNC VGNC:34256
Others S1PR5 NCBI