S1PR5 - sphingosine-1-phosphate receptor 5 Gene

Homo sapiens

Also known as EDG8; S1P5; Edg-8; SPPR-1; SPPR-2

Gene ID: 53637 | Gene type: protein coding

About S1PR5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,512,742-10,517,965 (from NCBI)

This gene has 3 transcripts (splice variants), 236 orthologues and 18 paralogues. Biased expression in skin (RPKM 5.9), bone marrow (RPKM 5.0) and 10 other tissues.

Summary

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, Apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; Others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

S1PR5 Products(2)

mRNA	Protein	Name
NM_001166215.2	NP_001159687.1	sphingosine 1-phosphate receptor 5
NM_030760.5	NP_110387.1	sphingosine 1-phosphate receptor 5

S1PR5 Protein Structure

7tm_1

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 5

S1P receptor 5	S1P receptor Edg-8
endothelial differentiation G-protein-coupled receptor 8	endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
sphingosine 1-phosphate receptor EDG8	sphingosine 1-phosphate receptor Edg-8

Related Diseases

Diseases

Alias

Secondary Progressive Multiple Sclerosis

Secondary-Progressive Ms	Spms
Multiple Sclerosis, Chronic Progressive	Chronic Progressive Multiple Sclerosis
Multiple Sclerosis, Secondary Progressive

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Second-Degree Atrioventricular Block

Second-Degree Heart Block	Second Degree Atrioventricular Block
Second Degree Atrioventricular Heart Block	Second Degree Heart Block
Incomplete Atrioventricular Block, Second Degree Nos	Second-Degree Block, Type 1 And 2
Atrioventricular Block, Type 1 And 2	Second Degree Incomplete Atrioventricular Block
Av - [Atrioventricular] Block 2nd

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	98.88%	Yes
HY-12288	Ozanimod	Agonist	99.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12288A	Ozanimod hydrochloride	Modulator	99.19%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136578	RP101988	Agonist	98.92%	Unkown
HY-111253	CYM-5478	Agonist	/	Unkown
HY-148198	S1P5 receptor agonist-1	Agonist	/	Unkown
HY-136576	RP101075	Agonist	/	Unkown
HY-148115	S1p receptor agonist 2	Agonist	/	Unkown
HY-136577	RP101442	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	S1PR5	MGD	MGI:2150641
Rattus norvegicus	S1PR5	RGD	RGD:620566
Canis familiaris	S1PR5	VGNC	VGNC:45838
Macaca mulatta	S1PR5	VGNC	VGNC:77015
Bos taurus	S1PR5	VGNC	VGNC:34256

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