Acss2 - acyl-CoA synthetase short-chain family member 2 Gene

Also Known as ACS; ACAS; Acs1; Acas1; Acas2; aceCS; AceCS1; 1110017C11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 60525

Summary

Enables acetate-CoA Ligase activity and propionate-CoA Ligase activity. Acts upstream of or within acetyl-CoA biosynthetic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Acss2 Products (1)

mRNA Protein Name
NM_019811.3 NP_062785.2 acetyl-coenzyme A synthetase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetate-CoA ligase activity IDA
IDA: Inferred from direct assay
11150295 MGI
enables acetate-CoA ligase activity IMP
IMP: Inferred from mutant phenotype
28562591 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
28562591 MGI
enables propionate-CoA ligase activity IDA
IDA: Inferred from direct assay
11150295 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28562591 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
28562591 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acetyl-CoA biosynthetic process IDA
IDA: Inferred from direct assay
11150295 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
28562591 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11150295 MGI
located in cytosol IDA
IDA: Inferred from direct assay
28552616 MGI
located in nucleus IDA
IDA: Inferred from direct assay
28552616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acetyl-coenzyme A synthetase, cytoplasmic

  • acetate--CoA ligase

  • acetyl-CoA synthetase 1

  • acetyl-Coenzyme A synthetase 1 (AMP forming)

  • acetyl-Coenzyme A synthetase 2 (ADP forming)

  • acetyl-Coenzyme A synthetase 2 (AMP forming)

  • acyl-activating enzyme

  • propionate--CoA ligase

Recombinant Acss2 Proteins

Cat. No. Product Name Accession Purity
HY-P71642 ACSS2 Protein, Mouse (His) Q9QXG4 (M1-Q701) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104032 Ac-CoA Synthase-IN-1 Inhibitor 99.70% Unkown
HY-W105310A Croconic acid disodium 99.98% Unkown
HY-145953 VY-3-135 Inhibitor 99.62% Unkown
HY-148104 ACSS2-IN-2 Inhibitor 99.49% Unkown
HY-N0059 D-Arabinose ≥99.0% Unkown
HY-N2353 Arabinose 99.87% Unkown
HY-N7082 D-Arabinopyranose 99.94% Unkown
HY-161116 AD-5584 Inhibitor 99.86% Unkown
HY-161117 AD-8007 Inhibitor 99.36% Unkown
HY-RS00211 ACSS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145392 ACSS2-IN-1 Inhibitor / Unkown
HY-183249 Ac-CoA Synthase-IN-2 Inhibitor / Unkown
HY-N0059R D-Arabinose (Standard) / Unkown
HY-N0059S D-Arabinose-13C / Unkown
HY-N0059S1 D-Arabinose-13C-1 / Unkown
HY-N0059S2 D-arabinose-13C-2 / Unkown
HY-N0059S3 D-Arabinose-13C-3 / Unkown
HY-N0059S4 D-Arabinose-d2 / Unkown
HY-N0059S5 D-Arabinose-d5 / Unkown
HY-N0059S6 D-Arabinose-d6 / Unkown
HY-N7082S D-Arabinopyranose-13C5 99.9% Unkown
HY-104032R Ac-CoA Synthase-IN-1 (Standard) Inhibitor / Unkown
HY-RS16673 Acss2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23108 Acss2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acss2 NCBI NCBI:55902