CCL13 - C-C motif chemokine ligand 13 Gene

Also Known as NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6357

About CCL13

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,356,480-34,358,610 (from NCBI)

This gene has 2 transcripts (splice variants), 79 orthologues and 25 paralogues. Broad expression in colon (RPKM 14.2), small intestine (RPKM 11.9) and 14 other tissues.

Summary

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

CCL13 Products (1)

mRNA Protein Name
NM_005408.3 NP_005399.1 C-C motif chemokine 13 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
10072545 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28381538 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12949249 GOA
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
10072545 GOA
involved in eosinophil chemotaxis IDA
IDA: Inferred from direct assay
10072545 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
12949249 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
10072545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL13 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 89)

  • 0
  • 98 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 13

  • CK-beta-10

CCL13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCL13 Q99616 XCL1 Homo sapiens P47992
Filter Binding
28381538
Intra
CCL13 Q99616 PF4 Homo sapiens P02776
SPR
28381538
Intra
CCL13 Q99616 CCL5 Homo sapiens P13501
SPR
28381538
Intra
CCL13 Q99616 CCL5 Homo sapiens P13501
Filter Binding
28381538
Intra
CCL13 Q99616 CXCL11 Homo sapiens O14625
Filter Binding
28381538
Intra
CCL13 Q99616 CXCL12 Homo sapiens P48061
SPR
28381538
Intra
CCL13 Q99616 CXCL12 Homo sapiens P48061
Filter Binding
28381538
Intra
CCL13 Q99616 CCL26 Homo sapiens Q9Y258
Filter Binding
28381538
Intra
CCL13 Q99616 CXCL10 Homo sapiens P02778
Filter Binding
28381538
Intra
CCL13 Q99616 CCL21 Homo sapiens O00585
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL13 Proteins

Cat. No. Product Name Accession Purity
HY-P7245 MCP-4/CCL13 Protein, Human Q99616 (Q24-T98) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Mansonelliasis

  • Mansonellosis

  • Mansonella Perstans Infections

  • Mansonella Infestation
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Allergic Disease

  • Hypersensitivity

  • Allergic Hypersensitivity Disease

  • Allergic Condition

  • Allergic Reaction

  • Allergic Disposition
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-165528 Histamine glutarimide Inhibitor / Unkown
HY-RS02082 CCL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174770 Human CCL13 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CCL13 VGNC VGNC:70696
Mus musculus CCL13 MGD MGI:98259
Rattus norvegicus CCL13 RGD RGD:1309255
Others CCL13 NCBI