BAD - Bad BCL2-associated agonist of cell death Gene

Also Known as Bad_v1; Bad_v2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64639

Summary

Enables 14-3-3 protein binding activity; protein kinase B binding activity; and protein Phosphatase 2B binding activity. Involved in several processes, including cellular response to chromate; positive regulation of cell death; and response to steroid hormone. Located in cytosol and mitochondrion. Used to study several diseases, including Parkinsonism; diabetic neuropathy; gastric ulcer; impotence; and middle cerebral artery infarction. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); brain disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic Cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]

BAD Products (1)

mRNA Protein Name
NM_022698.2 NP_073189.1 bcl2-associated agonist of cell death

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
22757651 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10579309 RGD
enables protein kinase B binding IPI
IPI: Inferred from physical interaction
15120593 RGD
enables protein phosphatase 2B binding IPI
IPI: Inferred from physical interaction
15120593 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to chromate IEP
IEP: Inferred from expression pattern
21262251 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9813151 RGD
involved in positive regulation of granulosa cell apoptotic process IDA
IDA: Inferred from direct assay
9389536 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17967733 RGD
involved in response to benzene IEP
IEP: Inferred from expression pattern
18093815 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
17663748 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17196335 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17283395 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
15845918 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15596134 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
18078455 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17978575 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16005992 RGD
involved in response to oleic acid IEP
IEP: Inferred from expression pattern
15627513 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15625305 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
15941375 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16011741 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12099715 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
22513421 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl2-associated agonist of cell death

  • Bcl2-antagonist of cell death

  • bcl-2 associated death agonist

  • bcl-2-binding component 6

  • bcl-xL/Bcl-2-associated death promoter

  • bcl2 antagonist of cell death

  • bcl2-associated death promoter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13495 ML281 Degrader 98.04% Unkown
HY-N1983 Caudatin 99.95% Unkown
HY-180190 Tubulin polymerization-IN-85 / Unkown
HY-182937 FLC-8 Modulator / Unkown
HY-180948 PZ-11 / Unkown
HY-181599 XAN-5 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BAD NCBI NCBI:572