Mertk - MER proto-oncogene, tyrosine kinase Gene

Also Known as rdy

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65037

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in phagocytosis; positive regulation of phagocytosis; and protein phosphorylation. Located in photoreceptor outer segment. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (Mer proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mertk Products (1)

mRNA Protein Name
NM_022943.1 NP_075232.1 tyrosine-protein kinase Mer precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in phagocytosis IDA
IDA: Inferred from direct assay
11861639 RGD
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
11861639 RGD
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
11592982 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11861639 RGD
Cellular Component GO Annotation Evidence References Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
11861639 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Mer

  • Receptor tyrosine tinase gene probably the gene for Rdy

  • c-mer proto-oncogene tyrosine kinase

  • proto-oncogene c-Mer

  • proto-oncogene tyrosine-protein kinase MER

  • receptor tyrosine kinase MerTK

  • retinal dystrophy

Recombinant Mertk Proteins

Cat. No. Product Name Accession Purity
HY-P700594 MERTK Protein, Rat (HEK293, His) P57097 (G19-M497) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-101549 MRX-2843 Inhibitor 99.92% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-147218 PF-07265807 Inhibitor 95.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12344 UNC2025 Inhibitor 99.92% Unkown
HY-12494 LDC1267 Inhibitor 99.64% Unkown
HY-132200 UNC5293 Inhibitor 99.93% Unkown
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-125510 UNC2541 Inhibitor 99.71% Unkown
HY-12344A UNC2025 hydrochloride Inhibitor 99.96% Unkown
HY-117548 UNC1062 98.92% Unkown
HY-173268 UNC9426 Inhibitor 99.51% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-162940 MerTK/Axl-IN-1 Inhibitor / Unkown
HY-172796 UNC9435 Inhibitor 98.08% Unkown
HY-RS08340 MERTK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N9454 Garcinoic acid / Unkown
HY-RS16678 Mertk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-115778 UNC3133 Inhibitor / Unkown
HY-162406 UNC8969 / Unkown
HY-169208 MerTK-IN-1 Inhibitor / Unkown
HY-173400 UNC8212 Inhibitor / Unkown
HY-174160 MerTK-IN-2 / Unkown
HY-176482 MerTK-IN-3 Inhibitor / Unkown
HY-101549A MRX-2843 hydrochloride Inhibitor / Unkown
HY-RS23113 Mertk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mertk NCBI NCBI:10461