MERTK - MER proto-oncogene, tyrosine kinase Gene

Also Known as MER; RP38; c-Eyk; c-mer; Tyro12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10461

About MERTK

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,898,607-112,029,561 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues, 53 paralogues and is associated with 3 phenotypes. Broad expression in adrenal (RPKM 25.0), spleen (RPKM 11.3) and 21 other tissues.

Summary

This gene is a member of the Mer/Axl/Tyro3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

MERTK Products (1)

mRNA Protein Name
NM_006343.3 NP_006334.2 tyrosine-protein kinase Mer precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20103767 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of leukocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
23353780 GOA
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
19204785 GOA
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
18395422 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18395422 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
18395422 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MERTK Protein Structure

I-set

I-set: Immunoglobulin I-set domain (96 - 179)

Ig_2

Ig_2: Immunoglobulin domain (203 - 280)

fn3

fn3: Fibronectin type III domain (285 - 369)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (588 - 852)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 999 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase Mer

  • MER receptor tyrosine kinase

Recombinant MERTK Proteins

Cat. No. Product Name Accession Purity
HY-P73821 Mer Protein, Human (sf9, His-GST) Q12866 (E578-Y872) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73822 Mer Protein, Human (sf9) Q12866 (E578-Y872) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73823 Mer Protein, Human (HEK293, His-Fc) Q12866 (A21-A499) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73824 Mer Protein, Human (HEK293) Q12866 (A21-A499) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78489 Mer Protein, Human (HEK293, mFc) Q12866 (A21-I505) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700442 MERTK Protein, Human (HEK293, His) Q12866 (A21-I505) ≥ 95%, as determined by reducing SDS-PAGE.

MERTK Antibodies

Cat. No. Product Name Application Reactivity
HY-P83221 MERTK Antibody (YA2966) WB, IHC-P, IP Human
HY-P84517 MERTK Antibody (YA4214) WB, ICC/IF, FC, ELISA Human, Mouse
HY-P84517A MERTK Antibody (YA4214)(PBS only) WB, ICC/IF, FC, ELISA Human
HY-P85277 MERTK Antibody (YA4969) WB; IHC-P; IHC-F; IF-Tissue Human

Related Diseases

Diseases Alias
Retinitis Pigmentosa 38

  • RP38

  • Rod-Cone Dystrophy, Childhood-Onset

  • Retinitis Pigmentosa, Type 38
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Retinitis
Retinoschisis 1, X-Linked, Juvenile

  • Retinoschisis

  • X-Linked Retinoschisis

  • X-Linked Juvenile Retinoschisis

  • RS1

  • XLRS1

  • X-Linked Juvenile Retinoschisis 1

  • Xlrs

  • Retinoschisis, X-Linked

  • Rs

  • Congenital X-Linked Retinoschisis

  • Degenerative Retinoschisis

  • Juvenile Retinoschisis

  • Xjr

  • Retinoschisis Juvenile X-Linked 1

  • Retinoschisis, Juvenile, X-Linked

  • Retinoschisis, Degenerative
La Crosse Encephalitis

  • California Encephalitis

  • California Virus Encephalitis

  • Neuroinvasive California Encephalitis Virus Infection

  • Californian Encephalitis

  • Encephalitis, California

  • California Meningoencephalitis

  • California Encephalitis Virus Infection

  • California Encephalitis Virus Infection Neuroinvasive Disease

  • California Meningoencephalitis Virus Disease

  • California Serogroup Virus Neuroinvasive Disease

  • California Viral Encephalitis

  • Ce - [California Encephalitis]

  • Lac - [La Crosse Encephalitis]
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Retinal Degeneration

  • Degeneration Of Retina
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Leber Congenital Amaurosis 2

  • LCA2

  • Amaurosis Congenita Of Leber Ii

  • Amaurosis Congenita Of Leber, Type 2

  • Leber Congenital Amaurosis Type Ii

  • Leber Congenital Amaurosis, Type 2

  • Leber Congenital Amaurosis, Type Ii
Filamentary Keratitis
Choroid Disease

  • Choroid Diseases

  • Abnormality Of The Choroid
Eye Degenerative Disease
Stargardt Disease

  • Stargardt Disease 1

  • Stargardt Macular Dystrophy

  • Stargardt Disease-1

  • Juvenile Onset Macular Degeneration

  • Stargardt Macular Degeneration

  • Juvenile Macular Degeneration

  • Macular Dystrophy With Flecks, Type 1

  • Stgd

  • Fundus Flavimaculatus

  • Stargardt 1

  • Stargardts Disease
Choroideremia

  • CHM

  • Tcd

  • Progressive Tapetochoroidal Dystrophy

  • Choroidal Sclerosis

  • Tapetochoroidal Dystrophy, Progressive

  • Progressive Choroidal Atrophy

  • Tapetochoroidal Dystrophy
Retinitis Pigmentosa 50

  • RP50

  • Retinitis Pigmentosa, Concentric

  • Retinitis Pigmentosa-50

  • Retinitis Pigmentosa Concentric
Degeneration Of Macula And Posterior Pole

  • Degeneration Of Macula And Posterior Pole Of Retina

  • Degeneration Of Macula Or Posterior Pole

  • Macular Degeneration Nos

  • Degenerative Disorder Of Macula

  • Drusen Macular Degeneration

  • Posterior Pole Macular Degeneration Of Eye

  • Macular Eye Degeneration

  • Macular Degeneration Of Retina, Unspecified

  • Pseudohole Degeneration Of Macula Of Retina
Vitelliform Macular Dystrophy

  • Best Disease

  • Juvenile-Onset Vitelliform Macular Dystrophy

  • Macular Dystrophy, Vitelliform

  • Best Macular Dystrophy

  • Vitelliform Dystrophy
Achromatopsia

  • Achm

  • Rod Monochromatism

  • Total Color Blindness

  • Rod Monochromacy

  • Monochromatism

  • Achromatism

  • Complete Or Incomplete Color Blindness

  • Pingelapese Blindness

  • Achromatopsia 1

  • Achromatopsia 2

  • Achromatopsia 3
Cone Dystrophy

  • Retinal Cone Dystrophy

  • Dystrophy, Cone

  • Cone Dystrophy 3
Achromatopsia 7

  • ACHM7

  • Achromatopsia, Type 7
Usher Syndrome

  • Deafness-Retinitis Pigmentosa Syndrome

  • Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

  • Graefe-Usher Syndrome

  • Hallgren Syndrome

  • Usher'S Syndrome

  • Retinitis Pigmentosa-Deafness Syndrome

  • Retinitis Pigmentosa-Hearing Loss Syndrome

  • Ush

  • Usher Syndromes
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101549 MRX-2843 Inhibitor 99.92% Phase 2
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-147218 PF-07265807 Inhibitor 95.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12344 UNC2025 Inhibitor 99.92% Unkown
HY-12494 LDC1267 Inhibitor 99.64% Unkown
HY-132200 UNC5293 Inhibitor 99.93% Unkown
HY-125510 UNC2541 Inhibitor 99.71% Unkown
HY-12344A UNC2025 hydrochloride Inhibitor 99.96% Unkown
HY-117548 UNC1062 98.92% Unkown
HY-173268 UNC9426 Inhibitor 99.51% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-162940 MerTK/Axl-IN-1 Inhibitor / Unkown
HY-172796 UNC9435 Inhibitor / Unkown
HY-RS08340 MERTK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N9454 Garcinoic acid / Unkown
HY-RS16678 Mertk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-115778 UNC3133 Inhibitor / Unkown
HY-162406 UNC8969 / Unkown
HY-169208 MerTK-IN-1 Inhibitor / Unkown
HY-173400 UNC8212 Inhibitor / Unkown
HY-174160 MerTK-IN-2 / Unkown
HY-176482 MerTK-IN-3 Inhibitor / Unkown
HY-101549A MRX-2843 hydrochloride Inhibitor / Unkown
HY-RS23113 Mertk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MERTK MGD MGI:96965
Felis catus MERTK VGNC VGNC:68237
Macaca mulatta MERTK VGNC VGNC:74706
Canis familiaris MERTK VGNC VGNC:43162
Bos taurus MERTK VGNC VGNC:31391
Rattus norvegicus MERTK RGD RGD:69283
Others MERTK NCBI