MERTK - MER proto-oncogene, tyrosine kinase Gene

Homo sapiens

Also known as MER; RP38; c-Eyk; c-mer; Tyro12

Gene ID: 10461 | Gene type: protein coding

About MERTK

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,898,607-112,029,561 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues, 53 paralogues and is associated with 3 phenotypes. Broad expression in adrenal (RPKM 25.0), spleen (RPKM 11.3) and 21 other tissues.

Summary

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

MERTK Products(1)

mRNA	Protein	Name
NM_006343.3	NP_006334.2	tyrosine-protein kinase Mer precursor

MERTK Protein Structure

I-set

Ig_2

fn3

Pkinase_Tyr

0
200
400
600
800
999 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Mer

MER receptor tyrosine kinase

Recombinant MERTK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73821	Mer Protein, Human (sf9, His-GST)	Q12866 (E578-Y872)	≥95%
HY-P73822	Mer Protein, Human (sf9)	Q12866 (E578-Y872)	≥95%
HY-P73823	Mer Protein, Human (HEK293, His-Fc)	Q12866 (A21-A499)	≥95%
HY-P73824	Mer Protein, Human (HEK293)	Q12866 (A21-A499)	≥95%
HY-P78489	Mer Protein, Human (HEK293, mFc)	Q12866 (A21-I505)	≥95%
HY-P700442	MERTK Protein, Human (HEK293, His)	Q12866 (A21-I505)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 38

RP38	Rod-Cone Dystrophy, Childhood-Onset
Retinitis Pigmentosa, Type 38

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis

Retinoschisis 1, X-Linked, Juvenile

Retinoschisis	X-Linked Retinoschisis
X-Linked Juvenile Retinoschisis	RS1
XLRS1	X-Linked Juvenile Retinoschisis 1
Xlrs	Retinoschisis, X-Linked
Rs	Congenital X-Linked Retinoschisis
Degenerative Retinoschisis	Juvenile Retinoschisis
Xjr	Retinoschisis Juvenile X-Linked 1
Retinoschisis, Juvenile, X-Linked	Retinoschisis, Degenerative

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Retinal Degeneration

Degeneration Of Retina

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Leber Congenital Amaurosis 2

LCA2	Amaurosis Congenita Of Leber Ii
Amaurosis Congenita Of Leber, Type 2	Leber Congenital Amaurosis Type Ii
Leber Congenital Amaurosis, Type 2	Leber Congenital Amaurosis, Type Ii

Filamentary Keratitis

Choroid Disease

Choroid Diseases

Abnormality Of The Choroid

Eye Degenerative Disease

Stargardt Disease

Stargardt Disease 1	Stargardt Macular Dystrophy
Stargardt Disease-1	Juvenile Onset Macular Degeneration
Stargardt Macular Degeneration	Juvenile Macular Degeneration
Macular Dystrophy With Flecks, Type 1	Stgd
Fundus Flavimaculatus	Stargardt 1
Stargardts Disease

Choroideremia

CHM	Tcd
Progressive Tapetochoroidal Dystrophy	Choroidal Sclerosis
Tapetochoroidal Dystrophy, Progressive	Progressive Choroidal Atrophy
Tapetochoroidal Dystrophy

Retinitis Pigmentosa 50

RP50	Retinitis Pigmentosa, Concentric
Retinitis Pigmentosa-50	Retinitis Pigmentosa Concentric

Degeneration Of Macula And Posterior Pole

Degeneration Of Macula And Posterior Pole Of Retina	Degeneration Of Macula Or Posterior Pole
Macular Degeneration Nos	Degenerative Disorder Of Macula
Drusen Macular Degeneration	Posterior Pole Macular Degeneration Of Eye
Macular Eye Degeneration	Macular Degeneration Of Retina, Unspecified
Pseudohole Degeneration Of Macula Of Retina

Vitelliform Macular Dystrophy

Best Disease	Juvenile-Onset Vitelliform Macular Dystrophy
Macular Dystrophy, Vitelliform	Best Macular Dystrophy
Vitelliform Dystrophy

Achromatopsia

Achm	Rod Monochromatism
Total Color Blindness	Rod Monochromacy
Monochromatism	Achromatism
Complete Or Incomplete Color Blindness	Pingelapese Blindness
Achromatopsia 1	Achromatopsia 2
Achromatopsia 3

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Achromatopsia 7

ACHM7

Achromatopsia, Type 7

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2
HY-101549	MRX-2843	Inhibitor	99.70%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12344	UNC2025	Inhibitor	99.83%	Unkown
HY-125510	UNC2541	Inhibitor	99.71%	Unkown
HY-12344A	UNC2025 hydrochloride	Inhibitor	99.87%	Unkown
HY-132200	UNC5293	Inhibitor	95.07%	Unkown
HY-117548	UNC1062	Inhibitor	99.48%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-131909	CJ-2360	Inhibitor	/	Unkown
HY-RS08340	MERTK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MERTK	MGD	MGI:96965
Felis catus	MERTK	VGNC	VGNC:68237
Macaca mulatta	MERTK	VGNC	VGNC:74706
Canis familiaris	MERTK	VGNC	VGNC:43162
Bos taurus	MERTK	VGNC	VGNC:31391
Rattus norvegicus	MERTK	RGD	RGD:69283
Macaca fascicularis	MERTK	NCBI
Others	MERTK	NCBI

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