SLPI - secretory leukocyte peptidase inhibitor Gene

Also Known as ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6590

About SLPI

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,252,239-45,254,564 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 9 paralogues. Biased expression in salivary gland (RPKM 1077.5), lung (RPKM 390.4) and 4 other tissues.

Summary

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte Elastase, and Cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic Enzymes. This antimicrobial protein has Antibacterial, Antifungal and Antiviral activity. [provided by RefSeq, Nov 2014]

SLPI Products (1)

mRNA	Protein	Name
NM_003064.4	NP_003055.1	antileukoproteinase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	2467900	GOA
enables endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	12526812	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19333378	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	2467900	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12526812	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	3462719	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	18714013	GOA
involved in modulation of process of another organism	IDA IDA: Inferred from direct assay	2467900	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	19333378	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	19333378	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	3462719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLPI Protein Structure

WAP

0
100
132 a.a.

Protein Preferred Names	Protein Names
antileukoproteinase	HUSI-1

SLPI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLPI	P03973	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	SLPI	P03973	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	SLPI	P03973	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	SLPI	P03973	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	SLPI	P03973	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	SLPI	P03973	NBL1	Homo sapiens	P41271-2	Validated Y2H	32296183
Intra	SLPI	P03973	CALN1	Homo sapiens	Q9BXU9	Validated Y2H	32296183
Intra	SLPI	P03973	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	SLPI	P03973	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	SLPI	P03973	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	SLPI	P03973	SMIM14	Homo sapiens	Q96QK8	Validated Y2H	32296183
Intra	SLPI	P03973	EFEMP1	Homo sapiens	Q12805	Validated Y2H	32296183
Intra	SLPI	P03973	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	SLPI	P03973	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	SLPI	P03973	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	SLPI	P03973	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	SLPI	P03973	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	SLPI	P03973	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	SLPI	P03973	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLPI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73414	SLPI Protein, Human (sf9, His)	P03973 (S26-A132)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73414A	SLPI Protein, Human (sf9, His, solution)	P03973 (S26-A132)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78548	SLPI Protein, Human (HEK293, Fc)	P03973 (S26-A132)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Trichomoniasis	Trichomonas Infection Trichomonas Infections Disease Due To Trichomonadidae Infection By Trichomonas Trichomonadosis Trichomonas Pruritus Trichomonosis Tricomoniasis
Pustular Psoriasis
Renal Osteodystrophy	Renal Rickets Chronic Kidney Disease-Mineral And Bone Disorder
Pulmonary Emphysema
Bronchitis	Chronic Bronchitis Acute Bronchitis Bronchitis, Chronic Acute Bronchitis And Bronchiolitis Chest Cold Chest Infection Ci - Chest Infection Recurrent Wheezy Bronchitis Bronchitis Chronic Lower Respiratory Tract Infection Acute Lower Respiratory Tract Infection Chronic Bronchitis Nos Senile Bronchitis Bronchitis Nos In Those Under L5 Years Of Age Bronchitis Nos
Alpha-1-Antitrypsin Deficiency	Alpha 1-Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Aat Deficiency Aatd A1ATD Emphysema Due To Aat Deficiency A1at Deficiency Emphysema-Cirrhosis, Due To Aat Deficiency Hemorrhagic Diathesis Due To Antithrombin Pittsburgh Alpha-1 Antiprotease Deficiency Alpha 1 Antitrypsin Deficiency Aat Alpha-1 Protease Inhibitor Deficiency Alpha-1 Related Emphysema Genetic Emphysema Hereditary Pulmonary Emphysema Inherited Emphysema Alpha-1-Proteinase Inhibitor Deficiency Alpha1-Antitrypsin Deficiency Alpha-1-Antitrypsin Deficiency, Autosomal Recessive Emphysema, Hereditary Pulmonary Aatd - [Alpha-1-Antitrypsin] Deficiency
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Bronchiectasis	Polynesian Bronchiectasis Kartagener Syndrome Bronchiectasis Nos
Pasteurellosis	Pasteurella Infection Pasteurella Infections Pasteurella Infectious Disease Shipping Fever Transport Fever
Vaginal Disease	Vaginal Diseases
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Vaginitis	Infective Vaginitis Inflammation Of Vagina Colpitis Vaginal Inflammation Vaginitis Nos
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Farmer'S Lung	Farmer Lung Farmers Lung Farmer'S Lung Disease Farmers' Lung Farmers' Lung Disease Mouldy Hay Disease Moldy Hay Disorder Fibrosis Of Lung With Farmers' Lung Harvesters' Hypersensitivity Pneumonitis Moldy Hay Pneumoconiosis Haymakers' Hypersensitivity Pneumonitis Threshers' Lung Harvester Lung Haymaker Lung
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Corneal Abscess
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Chorioamnionitis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Gingivitis	Chronic Gingivitis Acute Gingivitis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Bacterial Vaginosis	Vaginosis, Bacterial
Hypophosphatasia	Phosphoethanolaminuria Childhood Hypophosphatasia Deficiency Of Alkaline Phosphatase Hypophospatasia, Childhood Hypophosphatasia Mild Phosphoethanol-Aminuria Rathburn Disease Hpp Rathbun Disease Hypophosphatasia, Childhood Infantile Hypophosphatasia
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Vaginal Discharge
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Fallopian Tube Disease	Fallopian Tube Diseases
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Psoriasis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Bacteremia 2	Bacteremia Bacteremia, Susceptibility To, 2 BACTS2 Bacteremia, Susceptibility To Bacteremia, Susceptibility To, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13382	SLPI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17168	Slpi Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23618	Slpi Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLPI	MGD	MGI:109297
Felis catus	SLPI	VGNC	VGNC:81222
Rattus norvegicus	SLPI	RGD	RGD:621768
Canis familiaris	SLPI	VGNC	VGNC:49651
Macaca mulatta	SLPI	VGNC	VGNC:108057
Others	SLPI	NCBI