CA1 - carbonic anhydrase 1 Gene

Also Known as CAB; CA-I; Car1; HEL-S-11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 759

About CA1

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,327,608-85,378,113 (from NCBI)

This gene has 25 transcripts (splice variants), 286 orthologues and 14 paralogues. Biased expression in bone marrow (RPKM 551.6) and colon (RPKM 322.2).

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

CA1 Products (7)

mRNA	Protein	Name
NM_001128830.4	NP_001122302.1	carbonic anhydrase 1 isoform a
NM_001128829.4	NP_001122301.1	carbonic anhydrase 1 isoform a
NM_001738.5	NP_001729.1	carbonic anhydrase 1 isoform a
NM_001128831.4	NP_001122303.1	carbonic anhydrase 1 isoform a
NM_001164830.2	NP_001158302.1	carbonic anhydrase 1 isoform a
NM_001291968.2	NP_001278897.1	carbonic anhydrase 1 isoform c
NM_001291967.2	NP_001278896.1	carbonic anhydrase 1 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables arylesterase activity	IMP IMP: Inferred from mutant phenotype	7758465	GOA
enables carbonate dehydratase activity	IDA IDA: Inferred from direct assay	10550681	GOA
enables carbonate dehydratase activity	IMP IMP: Inferred from mutant phenotype	7758465	GOA
enables cyanamide hydratase activity	IDA IDA: Inferred from direct assay	10550681	GOA
enables hydro-lyase activity	IDA IDA: Inferred from direct assay	2114290	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA1 Protein Structure

Carb_anhydrase

0
100
200
261 a.a.

Protein Preferred Names	Protein Names
carbonic anhydrase 1	carbonate dehydratase I carbonic anhydrase B carbonic anhydrase I cyanamide hydratase CA1 epididymis secretory protein Li 11 epididymis secretory sperm binding protein

CA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Validated Y2H	25910212
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Bait-Prey Pool	25910212
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Array	25910212
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7718	Carbonic Anhydrase 1 Protein, Human (His, solution)	P00915 (A2-F261)	≥ 95%, as determined by reducing SDS-PAGE.

CA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80382	Carbonic Anhydrase I Antibody (YA560)	WB, IHC-P	Human, Mouse, Rat
HY-P82237	Carbonic Anhydrase 1 Antibody (YA1982)	WB, IHC-P, ICC/IF	Human, Mouse, Rat, Zebrafish
HY-P85069	Carbonic Anhydrase 1 Antibody (YA4761)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Cataract 3, Multiple Types	Cataract 3 Multiple Types CTRCT3 Cca2 Cataract, Congenital, Cerulean Type, 2 Cataract 3, Multiple Types, With Or Without Microcornea Cataract 3 Multiple Types With Or Without Microcornea Congenital Cerulean Type Cataract 2 Congenital Cataract Blue Dot Type 2 Congenital Cataract Cerulean Type 2 Cspc Sutural Cataract With Punctate And Cerulean Opacities
Alzheimer Disease 11	Ad11 Alzheimer'S Disease 11 Alzheimer Disease, Familial, 11 Alzheimer Disease-11 Alzheimer'S Disease 11, Late Onset
Intracranial Hypertension, Idiopathic	Pseudotumor Cerebri Benign Intracranial Hypertension Idiopathic Intracranial Hypertension Iih Benign Intracran. Hypt.
Osteopetrosis, Autosomal Recessive 3	Osteopetrosis With Renal Tubular Acidosis Marble Brain Disease OPTB3 Guibaud-Vainsel Syndrome Carbonic Anhydrase Ii Deficiency Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis Autosomal Recessive Osteopetrosis 3 Carbonic Anhydrase 2 Deficiency Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis Osteopetrosis Autosomal Recessive 3 Autosomal Recessive Osteopetrosis Type 3 Guibaud Vainsel Syndrome Mixed Rta Mixed Renal Tubular Acidosis Renal Tubular Acidosis Type 3 Carbonic Anhydrase Ii Deficiency Syndrome Carbonic Anhydrase Ii Variant Osteopetrosis, Autosomal Recessive, Type 3 Carbonic Anhydrase 2
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Transient Global Amnesia	Amnesia, Transient Global

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0764	Bucladesine sodium	Activator	99.84%	Yes
HY-10932	Aniracetam	Modulator	99.94%	Unkown
HY-B1424	Benzthiazide	Inhibitor	99.70%	Unkown
HY-B1154	Penbutolol sulfate	Antagonist	98.89%	Unkown
HY-116790	(-)-Penbutolol	Antagonist	99.74%	Unkown
HY-B0764R	Bucladesine sodium (Standard)	Activator	99.81%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-Y0282	Sodium bromide		99.2%	Phase 3
HY-106865	Mivazerol		/	Phase 3
HY-10049	CP 122721	Antagonist	/	Phase 2
HY-107111	GSK1034702	Agonist	99.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2183	Baimaside	Inhibitor	99.57%	Unkown
HY-157786	XPC-5462	Inhibitor	99.65%	Unkown
HY-164288	TDI-6570	Inhibitor	99.64%	Unkown
HY-101955A	(2R,6R)-Hydroxynorketamine hydrochloride		99.91%	Unkown
HY-P3914	Cecropin A (1-7)-Melittin A (2-9)	Inhibitor	99.50%	Unkown
HY-100606	l-Pindolol		99.89%	Unkown
HY-136980	Aspartylglutamate		99.79%	Unkown
HY-103502	CGP7930	Modulator	99.0%	Unkown
HY-176550	ASIC1a antagonist-1	Antagonist	98.00%	Unkown
HY-P1387	β-Amyloid (1-40) (rat)	Inducer	/	Unkown
HY-RS12372	S100A10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N5130	Effusol		99.83%	Unkown
HY-106784A	(E)-Ajoene		95%	Unkown
HY-16147	Combretastatin A1 phosphate	Ligand	/	Unkown
HY-100843	L-AP6		/	Unkown
HY-107111A	GSK1034702 hydrochloride	Agonist	/	Unkown
HY-116431	I-BOP	Agonist	/	Unkown
HY-117578	KB 5666		/	Unkown
HY-124985	VU6010608	Modulator	/	Unkown
HY-135525	Agroclavine	Agonist	/	Unkown
HY-139145	Etbicyphat	Antagonist	98.0%	Unkown
HY-139145S	Etbicyphat-13C3		/	Unkown
HY-15080	GYKI 53405	Antagonist	/	Unkown
HY-159870	E12CA1A3		/	Unkown
HY-168320	N-Stearoyltyrosine	Inhibitor	/	Unkown
HY-170558	FW-1		/	Unkown
HY-174269	HIV Capsid-IN-2	Inhibitor	/	Unkown
HY-177573	Cholesteryl γ-aminobutyrate		/	Unkown
HY-182548	BTS 72664	Inhibitor	/	Unkown
HY-183101	AMPAR modulator-12		/	Unkown
HY-P4397	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin		/	Unkown
HY-RS01762	CA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01905	Car1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-116143	MAGL-IN-12	Inhibitor	/	Unkown
HY-14477	UPF-1035	Inhibitor	/	Unkown
HY-W051199	O-Phosphono-L-homoserine	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CA1	VGNC	VGNC:38604
Felis catus	CA1	VGNC	VGNC:60239
Rattus norvegicus	CA1	RGD	RGD:1309780
Macaca mulatta	CA1	VGNC	VGNC:83986
Mus musculus	CA1	MGD	MGI:88268
Others	CA1	NCBI