1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Benzthiazide

Benzthiazide 

Cat. No.: HY-B1424 Purity: 99.40%
Handling Instructions

Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells.

For research use only. We do not sell to patients.

Benzthiazide Chemical Structure

Benzthiazide Chemical Structure

CAS No. : 91-33-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg USD 70 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Benzthiazide is a long-acting diuretic[1] and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells[2].

IC50 & Target

Ki: 8.0 nM (CA9), 8.8 nM (CA2), 10 nM (CA1)[2]

In Vitro

Benzthiazide (0.4, 2, 10 μM) suppresses proliferation of cancer cell under hypoxic conditions in a dose-dependent manner
.
Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzthiazide (1, 1.5 mg/100 g BW) causes a marked decrease in urinary calcium excretion and the dissociation of calcium and sodium excretion in hyperprolactinemic rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

431.94

Formula

C₁₅H₁₄ClN₃O₄S₃

CAS No.

91-33-8

SMILES

O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC3=CC=CC=C3)=NS2(=O)=O)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3151 mL 11.5757 mL 23.1514 mL
5 mM 0.4630 mL 2.3151 mL 4.6303 mL
10 mM 0.2315 mL 1.1576 mL 2.3151 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BenzthiazideCarbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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Product Name:
Benzthiazide
Cat. No.:
HY-B1424
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