2. Gene
  3. Hpgd - 15-hydroxyprostaglandin dehydrogenase Gene

Hpgd - 15-hydroxyprostaglandin dehydrogenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 79242 | Gene type: protein coding

About Hpgd

Primary_assembly 16: 33,986,266-34,024,228 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 204 orthologues and is associated with 16 phenotypes. Biased expression in Lung (RPKM 31.9), Kidney (RPKM 262.4) and 5 other tissues.

Summary

Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in cytoplasm and extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Hpgd Products(1)

mRNA Protein Name
NM_024390.3 NP_077366.2 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Hpgd Protein Structure

ADH_SDR_c_like

ADH_SDR_c_like: cd05323 (5 - 253)

  • 0
  • 100
  • 200
  • 266 a.a.
Protein Preferred Names Protein Names

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

15-PGDH

NAD-dependent 15-hydroxyprostaglandin dehydrogenase

PGDH

eicosanoid/docosanoid dehydrogenase

hydroxyprostaglandin dehydrogenase 15 (NAD)

prostaglandin dehydrogenase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108259 HQL-79 Inhibitor 99.89% Unkown
HY-109134 Pizuglanstat Inhibitor 99.40% Unkown
HY-139972 PROTAC(H-PGDS)-7 Inhibitor 99.42% Unkown
HY-110167 TFC 007 Inhibitor ≥98.0% Unkown
HY-126134 HPGDS inhibitor 2 Inhibitor 99.72% Unkown
HY-12791 hPGDS-IN-1 Inhibitor 99.82% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.04% Unkown
HY-146662 HPGDS inhibitor 3 Inhibitor / Unkown
HY-157577 PROTAC(H-PGDS)-8 Degrader / Unkown
HY-RS06338 HPGD Human Pre-designed siRNA Set A / Unkown
HY-RS06339 Hpgd Mouse Pre-designed siRNA Set A / Unkown
HY-RS06340 Hpgd Rat Pre-designed siRNA Set A / Unkown
HY-RS06341 HPGDS Human Pre-designed siRNA Set A / Unkown
HY-139171 F092 Inhibitor 99.79% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpgd NCBI NCBI:3248
Mus musculus Hpgd NCBI NCBI:15446