Hpgd - 15-hydroxyprostaglandin dehydrogenase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79242

About Hpgd

Primary_assembly 16: 33,986,266-34,024,228 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 204 orthologues and is associated with 16 phenotypes. Biased expression in Lung (RPKM 31.9), Kidney (RPKM 262.4) and 5 other tissues.

Summary

Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in cytoplasm and extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Hpgd Products (1)

mRNA Protein Name
NM_024390.3 NP_077366.2 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
9099857 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
2251293 RGD
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
3338612 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
24647712 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
22580984 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
24657469 RGD
involved in prostaglandin metabolic process IDA
IDA: Inferred from direct assay
18058808 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
3478736 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
6574558 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12399253 RGD
involved in thrombin-activated receptor signaling pathway IEP
IEP: Inferred from expression pattern
19383433 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
24647712 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hpgd Protein Structure

ADH_SDR_c_like

ADH_SDR_c_like: cd05323 (5 - 253)

  • 0
  • 100
  • 200
  • 266 a.a.
Protein Preferred Names Protein Names

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

  • 15-PGDH

  • NAD-dependent 15-hydroxyprostaglandin dehydrogenase

  • PGDH

  • eicosanoid/docosanoid dehydrogenase

  • hydroxyprostaglandin dehydrogenase 15 (NAD)

  • prostaglandin dehydrogenase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-116449 2-Benzoylthiophene 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108259 HQL-79 Inhibitor 99.89% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.42% Unkown
HY-12791 hPGDS-IN-1 Inhibitor 99.92% Unkown
HY-139972 PROTAC(H-PGDS)-7 99.42% Unkown
HY-110167 TFC 007 Inhibitor 98.01% Unkown
HY-126134 HPGDS inhibitor 2 Inhibitor 99.70% Unkown
HY-146662 HPGDS inhibitor 3 Inhibitor / Unkown
HY-157577 PROTAC(H-PGDS)-8 Degrader / Unkown
HY-RS06338 HPGD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06339 Hpgd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06340 Hpgd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06341 HPGDS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120581 ML388 Inhibitor / Unkown
HY-139171 F092 Inhibitor 99.79% Unkown
HY-RS17229 Hpgds Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23682 Hpgds Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpgd NCBI NCBI:3248