Lat - linker for activation of T cells Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81511

Summary

Predicted to enable protein kinase binding activity and signaling receptor complex adaptor activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Predicted to act upstream of or within gene expression and lymphocyte homeostasis. Predicted to be located in Golgi apparatus; cell-cell junction; and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of COP9 signalosome. Predicted to be active in immunological synapse. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Apr 2022]

Lat Products (1)

mRNA Protein Name
NM_030853.1 NP_110480.1 linker for activation of T-cells family member 1
Protein Preferred Names Protein Names

linker for activation of T-cells family member 1

  • 36 kDa phospho-tyrosine adapter protein

  • p36-38

  • pp36

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14889 Fluciclovine / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164401 QBS10072S Inducer / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990610 KHK-2898 Inhibitor 97.16% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138489 TRULI Inhibitor 99.98% Unkown
HY-150042 TDI-011536 Inhibitor 99.91% Unkown
HY-108540 BCH Inducer 99.83% Unkown
HY-160769 NIBR-LTSi 99.97% Unkown
HY-147082 GA-017 98.95% Unkown
HY-16929 Latrunculin A Inhibitor 98.9% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-W087830 L-p-Boronophenylalanine 99.84% Unkown
HY-120139 KMH-233 Inhibitor 99.75% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-N8847 α-Ionone 94.30% Unkown
HY-130504 Propargyl-PEG1-acid 97.0% Unkown
HY-155978A RDN2150 TFA Inhibitor 99.80% Unkown
HY-176886 LATS-IN-2 Inhibitor 99.45% Unkown
HY-164254 Cardiomyocyte proliferation promoting agent-1 Inhibitor 99.87% Unkown
HY-N3999 Venuloside A 99.82% Unkown
HY-175247 DDO-4033 99.11% Unkown
HY-W267524 H-Phe(3-CF3)-OH / Unkown
HY-120139A (R)-KMH-233 Control / Unkown
HY-183513 L-Ala-BPA Substrate / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108540R BCH (Standard) Inducer 99.84% Unkown
HY-127042 6,7-Epoxy-latrunculin A Inhibitor / Unkown
HY-129934S Latanoprost ethyl amide-d4 / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-164401A QBS10072S dihydrochloride / Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-181743 Piezo1 agonist 2 Agonist / Unkown
HY-182254 AChE/BChE-IN-35 Inhibitor / Unkown
HY-183147A LAT1-IN-2 hydrochloride Substrate / Unkown
HY-RS07536 LAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09827 ORC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129934 Latanoprost ethyl amide / Unkown
HY-RS16816 Lat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17343 Lats1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18181 Lats2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21361 Lat2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23256 Lat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23797 Lats1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24655 Lats2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27880 Lat2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W246010 α,α-DiBn-DL-Gly Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lat NCBI NCBI:27040