Tnk1 - tyrosine kinase, non-receptor, 1 Gene

Also Known as Kos1; Tnk1a; Tnk1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83813

Summary

Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tnk1 Products (1)

mRNA Protein Name
NM_031880.3 NP_114086.3 non-receptor tyrosine-protein kinase TNK1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
12789265 MGI
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
12789265 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
12789265 MGI
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
12789265 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
12789265 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
12789265 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

non-receptor tyrosine-protein kinase TNK1

  • kinase of embryonic stem cells

  • non-receptor tyrosine kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-13968 JW 55 Inhibitor 99.83% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-147316 TP-5801 Inhibitor 98.55% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147316A TP-5801 TFA Inhibitor 99.55% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-152197 Tankyrase-IN-3 Inhibitor / Unkown
HY-152198 Tankyrase-IN-4 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-181752 FGFR3-IN-12 / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14837 TNK1 Human Pre-designed siRNA Set A / Unkown
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-RS18502 Tnk1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS24984 Tnk1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnk1 NCBI NCBI:8711