Setdb1 - SET domain, bifurcated 1 Gene

Also Known as ESET; KMT1E; mKIAA0067

Species: Mus musculus

Gene Type: protein coding
Gene ID: 84505

Summary

Enables DNA binding activity; Histone Methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within several processes, including histone H3-K9 trimethylation; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; long bone; oocyte; and white fat. Human ortholog(s) of this gene implicated in autistic disorder and lung Cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Setdb1 Products (3)

mRNA Protein Name
NM_001163641.1 NP_001157113.1 histone-lysine N-methyltransferase SETDB1 isoform a
NM_001163642.1 NP_001157114.1 histone-lysine N-methyltransferase SETDB1 isoform b
NM_018877.3 NP_061365.3 histone-lysine N-methyltransferase SETDB1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
22495301 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22079090 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
11791185 MGI
enables histone H3K9 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
22079090 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
20164836 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11791185 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
22876197 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
14993285 MGI
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: Inferred from mutant phenotype
20164836 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22079090 MGI
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: Inferred from mutant phenotype
20164836 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14993285 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETDB1

  • ERG-associated protein with SET domain

  • SET domain ERG-associated histone methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141539 SETDB1-TTD-IN-1 Activator 99.93% Unkown
HY-173156 UNC10013 Modulator 99.90% Unkown
HY-168992A UNC6535 TFA / Unkown
HY-141539A SETDB1-TTD-IN-1 TFA 99.77% Unkown
HY-168992 UNC6535 Inhibitor / Unkown
HY-181914 UNC7242 Antagonist / Unkown
HY-184362 P-SETDB1-4 / Unkown
HY-RS12748 SETDB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16697 Setdb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23131 Setdb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setdb1 NCBI NCBI:9869