PARG - poly(ADP-ribose) glycohydrolase Gene

Also Known as PARG99

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8505

About PARG

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:49,818,279-49,942,027 (from NCBI)

This gene has 7 transcripts (splice variants) and 245 orthologues. Ubiquitous expression in kidney (RPKM 6.5), testis (RPKM 6.1) and 25 other tissues.

Summary

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

PARG Products (15)

mRNA Protein Name
XR_007062014.1
XM_047425921.1 XP_047281877.1 poly(ADP-ribose) glycohydrolase isoform X2
NR_136756.3
NM_001324381.3 NP_001311310.1 poly(ADP-ribose) glycohydrolase isoform b
NM_001303486.3 NP_001290415.1 poly(ADP-ribose) glycohydrolase isoform b
NM_001303487.3 NP_001290416.1 poly(ADP-ribose) glycohydrolase isoform c
NR_130169.3
NR_130168.3
NM_001303489.3 NP_001290418.1 poly(ADP-ribose) glycohydrolase isoform d
NR_136755.3
NM_003631.5 NP_003622.2 poly(ADP-ribose) glycohydrolase isoform a
XM_011540305.2 XP_011538607.1 poly(ADP-ribose) glycohydrolase isoform X1
NR_136752.3
NR_136753.3
NR_136754.3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables poly(ADP-ribose) glycohydrolase activity IDA
IDA: Inferred from direct assay
9074616 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27257257 GOA
Biological Process GO Annotation Evidence References Source
involved in ATP generation from poly-ADP-D-ribose IDA
IDA: Inferred from direct assay
27257257 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9074616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARG Protein Structure

PARG_cat

PARG_cat: Poly (ADP-ribose) glycohydrolase (PARG) (93 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

poly(ADP-ribose) glycohydrolase

  • mitochondrial poly(ADP-ribose) glycohydrolase

Related Diseases

Diseases Alias
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

  • CONDSIAS

  • Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Osebold-Remondini Syndrome

  • Brachydactyly Type A6

  • Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

  • Bda6

  • Brachydactyly, Type A6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0889 Ethacridine lactate monohydrate Inhibitor 99.85% Unkown
HY-B2174 Ethacridine lactate Inhibitor 99.83% Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99965 Crovalimab Inhibitor 99.59% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-156881 PARG-IN-4 98.50% Phase 4

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108360 PDD 00017273 99.64% Unkown
HY-128760 COH34 99.97% Unkown
HY-146248B TFMU-ADPr diammonium 98.78% Unkown
HY-133531 PDD00017272 99.01% Unkown
HY-137924 JA2131 Inhibitor 99.7% Unkown
HY-133530 PDD00017238 98.71% Unkown
HY-178208 MDOLL-0286 Inhibitor 99.66% Unkown
HY-134354A pNP-ADPr disodium 98.08% Unkown
HY-122041 Ethacridine 98.60% Unkown
HY-135846 PDD00031705 99.47% Unkown
HY-115666 COH34 analog 1 98.75% Unkown
HY-146248A TFMU-ADPr triethylamine 97.26% Unkown
HY-164717 FORX-428 Inhibitor / Unkown
HY-134354 pNP-ADPr / Unkown
HY-146248 TFMU-ADPr / Unkown
HY-153574 BI01826025 Degrader / Unkown
HY-171789 PARG-IN-7 Inhibitor / Unkown
HY-177420 PDD00031704 Inhibitor / Unkown
HY-RS10040 PARG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10041 Parg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10042 Parg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PARG MGD MGI:1347094
Rattus norvegicus PARG RGD RGD:620387
Macaca mulatta PARG VGNC VGNC:106084
Canis familiaris PARG VGNC VGNC:53006
Others PARG NCBI