DDO - D-aspartate oxidase Gene

Also Known as DASOX; DASPO; DDO-1; DDO-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8528

About DDO

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,388,321-110,415,575 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 1 paralogue. Broad expression in heart (RPKM 7.9), kidney (RPKM 5.9) and 20 other tissues.

Summary

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]

DDO Products (8)

mRNA Protein Name
NM_001368170.1 NP_001355099.1 D-aspartate oxidase isoform c
NM_001368171.1 NP_001355100.1 D-aspartate oxidase isoform d
NM_001368172.1 NP_001355101.1 D-aspartate oxidase isoform e
NM_001368173.1 NP_001355102.1 D-aspartate oxidase isoform f
NM_001368174.1 NP_001355103.1 D-aspartate oxidase isoform g
NM_001368175.1 NP_001355104.1 D-aspartate oxidase isoform g
NM_001372108.2 NP_001359037.1 D-aspartate oxidase isoform h
NM_004032.3 NP_004023.3 D-aspartate oxidase isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-aspartate oxidase activity IDA
IDA: Inferred from direct assay
9163533 GOA
enables FAD binding IDA
IDA: Inferred from direct assay
20603179 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9820813 GOA
Biological Process GO Annotation Evidence References Source
involved in D-amino acid catabolic process IDA
IDA: Inferred from direct assay
20603179 GOA
involved in aspartate catabolic process IDA
IDA: Inferred from direct assay
9163533 GOA
involved in nervous system process IMP
IMP: Inferred from mutant phenotype
28560262 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
37805834 GOA
is active in peroxisome IDA
IDA: Inferred from direct assay
37805834 GOA
located in peroxisome IDA
IDA: Inferred from direct assay
1991137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDO Protein Structure

DAO

DAO: FAD dependent oxidoreductase (34 - 350)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

D-aspartate oxidase

  • D-aspartate oxidase, DDO

Related Diseases

Diseases Alias
Blackwater Fever

  • Black Water Fever

  • Hemoglobinuric, Malaria

  • Malarial Hemoglobinuria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-170915 DDO-3055 Inhibitor 99.64% Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155489 DDO-2728 98.64% Unkown
HY-139301 DDO-5936 Inhibitor 98.33% Unkown
HY-144634 DDO-7263 Activator 99.83% Unkown
HY-153331 DDO-2213 Inhibitor 98.84% Unkown
HY-169947 DDO-6079 Inhibitor 98.92% Unkown
HY-175247 DDO-4033 99.11% Unkown
HY-132233A DDO-2093 dihydrochloride Inhibitor 98.79% Unkown
HY-132233 DDO-2093 Inhibitor / Unkown
HY-147125 DDO-6600 99.2% Unkown
HY-178496 DDO3602 Degrader / Unkown
HY-144801A DDO-02005 Inhibitor / Unkown
HY-144801 DDO-02005 free base Inhibitor / Unkown
HY-144802 DDO-02001 Inhibitor / Unkown
HY-149863 DDO-8926 Inhibitor / Unkown
HY-152247 DDO3711 Inhibitor / Unkown
HY-169013 DDO-3733 Activator / Unkown
HY-170668 DDO-02267 Inhibitor / Unkown
HY-172210 DDO-8958 Inducer / Unkown
HY-176404 DDO-6691 Inhibitor / Unkown
HY-179203 N-Demethylonalespib Ligand / Unkown
HY-179208 N-Descyclopropanecarbaldehyde Olaparib suberic acid / Unkown
HY-184502 DDO-88109 Inhibitor / Unkown
HY-RS03618 DDO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19106 Ddo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25596 Ddo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W078592 1-Chloro-4-[2-chloro-1-(4-chlorophenyl)ethyl]benzene / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DDO RGD RGD:1595123
Felis catus DDO VGNC VGNC:61393
Bos taurus DDO VGNC VGNC:27951
Macaca mulatta DDO VGNC VGNC:104372
Mus musculus DDO MGD MGI:1925528
Canis familiaris DDO VGNC VGNC:39840
Others DDO NCBI