Enpp1 - ectonucleotide pyrophosphatase/phosphodiesterase 1 Gene

Also Known as Pc1; Npps

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85496

Summary

Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in several cellular components, including dendrite; neuronal cell body; and synapse. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Enpp1 Products (1)

mRNA Protein Name
NM_053535.2 NP_445987.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphodiesterase I activity IDA
IDA: Inferred from direct assay
17187902 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to acidic pH IEP
IEP: Inferred from expression pattern
26033523 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
21168404 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
24157151 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
24157151 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
10231554 RGD
involved in olfactory bulb development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
26746151 RGD
involved in striatum development IEP
IEP: Inferred from expression pattern
18565716 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
17046728 RGD
located in basal dendrite IDA
IDA: Inferred from direct assay
17046728 RGD
located in cell body IDA
IDA: Inferred from direct assay
22086174 RGD
located in cell projection IDA
IDA: Inferred from direct assay
22086174 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17046728 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19474315 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 1

  • E-NPP 1

  • phosphodiesterase I/nucleotide pyrophosphatase 1

  • plasma-cell membrane glycoprotein PC-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-176708 ISM5939 Inhibitor 99.79% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991677 Efmirenpase alfa / Phase 3

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129490 Enpp-1-IN-1 Inhibitor 99.19% Unkown
HY-147389 Enpp-1-IN-14 Inhibitor 99.67% Unkown
HY-139362 Enpp-1-IN-2 Inhibitor 99.51% Unkown
HY-143256 Enpp-1-IN-12 Inhibitor 99.28% Unkown
HY-141831 STF-1084 Inhibitor 99.92% Unkown
HY-155457 Enpp-1-IN-19 99.28% Unkown
HY-169804 ENPP3 Inhibitor 1 Inhibitor 99.43% Unkown
HY-158791 Enpp-1-IN-21 Inhibitor 99.07% Unkown
HY-153335 Enpp-1-IN-16 Inhibitor 98.46% Unkown
HY-163343 Enpp-1-IN-20 98.06% Unkown
HY-176296 Vizenpistat Inhibitor 99.14% Unkown
HY-143254 Enpp-1-IN-10 Inhibitor 98.64% Unkown
HY-149465 STF-1623 Inhibitor 99.90% Unkown
HY-145063 Enpp-1-IN-5 Inhibitor 98.16% Unkown
HY-153398 Enpp-1-IN-17 Inhibitor 99.65% Unkown
HY-173189 2-5A Inhibitor / Unkown
HY-143255 Enpp-1-IN-11 Inhibitor / Unkown
HY-145062 Enpp-1-IN-4 Inhibitor / Unkown
HY-145064 Enpp-1-IN-6 Inhibitor / Unkown
HY-145065 Enpp-1-IN-7 Inhibitor / Unkown
HY-145069 Enpp-1-IN-8 Inhibitor / Unkown
HY-145070 Enpp-1-IN-9 Inhibitor / Unkown
HY-147998 Enpp-1-IN-13 Inhibitor / Unkown
HY-153334 Enpp-1-IN-15 Inhibitor / Unkown
HY-157522 NCI-14465 Inhibitor / Unkown
HY-162911 Enpp-1-IN-22 Inhibitor / Unkown
HY-162912 Enpp-1-IN-23 Inhibitor / Unkown
HY-168147 Enpp-1-IN-24 Inhibitor / Unkown
HY-168491 Enpp-1-IN-25 / Unkown
HY-172527 CD73-IN-20 Inhibitor / Unkown
HY-172528 Enpp-1/3-IN-1 Inhibitor / Unkown
HY-175047 Enpp-1-IN-26 Inhibitor / Unkown
HY-175478 Enpp-1-IN-27 / Unkown
HY-176828 Enpp-1-IN-28 Inhibitor / Unkown
HY-176874 Enpp-1-IN-29 Inhibitor / Unkown
HY-181667 Enpp-1-IN-30 Inhibitor / Unkown
HY-182772 Enpp-1-IN-31 Inhibitor / Unkown
HY-184200 Enpp-1-IN-32 / Unkown
HY-RS04387 ENPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156205 CdnP-IN-1 Inhibitor / Unkown
HY-RS16545 Enpp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22977 Enpp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enpp1 NCBI NCBI:5167