ENPP1 - ectonucleotide pyrophosphatase/phosphodiesterase 1 Gene

Also Known as M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5167

About ENPP1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,808,020-131,895,155 (from NCBI)

This gene has 12 transcripts (splice variants), 225 orthologues, 6 paralogues and is associated with 10 phenotypes. Biased expression in placenta (RPKM 22.6), thyroid (RPKM 14.0) and 13 other tissues.

Summary

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II Transmembrane Glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and Insulin resistance. [provided by RefSeq, Jul 2008]

ENPP1 Products (1)

mRNA	Protein	Name
NM_006208.3	NP_006199.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	7830796	GOA
enables cyclic-GMP-AMP hydrolase activity	IDA IDA: Inferred from direct assay	25344812	GOA
enables dinucleotide phosphatase activity	IDA IDA: Inferred from direct assay	12746903	GOA
enables exonuclease activity	IDA IDA: Inferred from direct assay	22285541	GOA
enables insulin receptor binding	IDA IDA: Inferred from direct assay	7830796	GOA
enables nucleoside triphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	7830796	GOA
enables phosphatase activity	IDA IDA: Inferred from direct assay	28592560	GOA
enables phosphodiesterase I activity	IDA IDA: Inferred from direct assay	27467858	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11289049	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	7830796	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	7830796	GOA
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	25644539	GOA
involved in bone mineralization	IDA IDA: Inferred from direct assay	28652107	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	7830796	GOA
involved in gene expression	IDA IDA: Inferred from direct assay	28592560	GOA
involved in generation of precursor metabolites and energy	IDA IDA: Inferred from direct assay	12746903	GOA
involved in inorganic diphosphate transport	IDA IDA: Inferred from direct assay	10513816	GOA
involved in intracellular phosphate ion homeostasis	IDA IDA: Inferred from direct assay	11159191	GOA
involved in melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	28964717	GOA
involved in negative regulation of D-glucose import	IDA IDA: Inferred from direct assay	17849011	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	17849011	GOA
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	17849011	GOA
involved in negative regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	11289049	GOA
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	7830796	GOA
involved in negative regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	11289049	GOA
involved in nucleic acid metabolic process	IDA IDA: Inferred from direct assay	22285541	GOA
involved in nucleoside triphosphate catabolic process	IDA IDA: Inferred from direct assay	10513816	GOA
involved in phosphate ion homeostasis	IDA IDA: Inferred from direct assay	28652107	GOA
involved in phosphate-containing compound metabolic process	IDA IDA: Inferred from direct assay	10513816	GOA
involved in response to ATP	IDA IDA: Inferred from direct assay	25644539	GOA
involved in sequestering of triglyceride	IDA IDA: Inferred from direct assay	17849011	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	10513816	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11159191	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	25644539	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10513816	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP1 Protein Structure

Somatomedin_B

Phosphodiest

Endonuclease_NS

0
200
400
600
800
925 a.a.

Protein Preferred Names	Protein Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 1	E-NPP 1

ENPP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ENPP1	P22413	ABCG2	Homo sapiens	Q9UNQ0	PLA	26065921

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENPP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77923	ENPP-1 Protein, Human (HEK293, His)	P22413 (K98-D925)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700956	ENPP-1 Protein, Human (Biotinylated, HEK293, His-Avi)	P22413 (K98-D925)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cole Disease	Hypopigmentation-Punctate Palmoplantar Keratoderma Syndrome COLED Guttate Hypopigmentation And Punctate Palmoplantar Keratoderma With Or Without Ectopic Calcification Guttate Hypopigmentation Punctate Palmoplantar Keratoderma With Or Without Ectopic Calcification Guttate Hypopigmentation And Punctate Palmoplantar Keratoderma Hypopigmentation And Punctate Keratosis Of The Palms And Soles Col Hypopigmentation Disorder Albinoidism, Oculocutaneous, Autosomal Dominant
Hypophosphatemic Rickets, Autosomal Recessive, 2	ARHR2 Hypophosphatemia Autosomal Recessive Rickets, Hypophosphatemic, Autosomal Recessive, Type 2
Arterial Calcification, Generalized, Of Infancy, 1	GACI1 Gaci Idiopathic Infantile Arterial Calcification Iiac Arterial Calcification, Idiopathic Infantile Arteriopathy, Occlusive Infantile Arterial Calcification Of Infancy, Generalized, 1 Generalized Arterial Calcification Of Infancy Occlusive Infantile Arteriopathy Calcification, Arterial, Generalized, Infancy, Type 1 Arterial Calcification Of Infancy Vascular Calcification
Arterial Calcification Of Infancy	Idiopathic Infantile Arterial Calcification Generalized Arterial Calcification Of Infancy Iiac Occlusive Infantile Arteriopathy Infantile Arteriosclerosis Gaci Idiopathic Obliterative Arteriopathy Generalized Arterial Calcification In Infancy Arteriopathia Calcificans Infantum Diffuse Arterial Calcifying Elastopathy Of Infancy Infantile Calcifying Arteriopathy Medial Coronary Sclerosis Of Infancy Coronary Sclerosis, Medial, Of Infancy Calcification, Arterial, Generalized, Infancy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Autosomal Recessive Hypophosphatemic Rickets	Arhr Hypophosphatemic Rickets, Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Ossification Of The Posterior Longitudinal Ligament Of Spine	OPLL Ossification Of The Posterior Longitudinal Ligament Of The Spine Ossification Of Posterior Longitudinal Ligament Of Spine Ossification, Posterior Longitudinal Ligament Spine
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Hypercementosis	Cementation Hyperplasia
Chondrocalcinosis	Pseudogout Calcium Pyrophosphate Deposition Disease Familial Chondrocalcinosis Chondrocalcinosis Nos Cppd - [Calcium Pyrophosphate Deposition Disease] Cpdd - [Calcium Pyrophosphate Deposition Disease] Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site Chondrocalcinosis, Cause Unspecified Chondrocalcinosis Due To Pyrophosphate Crystals Chondrocalcinosis Articularis Calcium Pyrophosphate Arthritis And Periarthritis
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets
Rickets	Vitamin D Deficiency Vitamin D Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Hypophosphatasia	Phosphoethanolaminuria Childhood Hypophosphatasia Deficiency Of Alkaline Phosphatase Hypophospatasia, Childhood Hypophosphatasia Mild Phosphoethanol-Aminuria Rathburn Disease Hpp Rathbun Disease Hypophosphatasia, Childhood Infantile Hypophosphatasia
Hypophosphatemia	Vitamin D-Resistant Rickets Hereditary Hypophosphatemic Rickets Vdrr Vitamin D Resistant Rickets Hypophosphatemic Rickets, X-Linked Dominant Familial Hypophosphatemic Rickets
Calcinosis	Pathologic Calcification Pathologically Calcified Structure
Diabetes Mellitus	Diabetes
Craniometaphyseal Dysplasia, Autosomal Dominant	Craniometaphyseal Dysplasia CMDD Cmdj Cmd Autosomal Dominant Craniometaphyseal Dysplasia Craniometaphyseal Dysplasia, Jackson Type Craniometaphyseal Dysplasia Jackson Type Autosomal Recessive Craniometaphyseal Dysplasia Cmdr Dysplasia, Craniometaphyseal, Autosomal Dominant Craniometaphyseal Dysplasia, Autosomal Recessive Type
Calcification Of Joints And Arteries	Hereditary Arterial And Articular Multiple Calcification Syndrome CALJA Arterial Calcification Due To Cd73 Deficiency Arterial Calcification Due To Deficiency Of Cd73 Acdc Arterial Calcification And Distal Joint Calcification Arterial Calcification Due To Deficiency Of Cd73:Acdc Calcification Of Joints And Arteries Calja
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Hypophosphatasia, Adult	Adult Hypophosphatasia Odontohypophosphatasia Hypophosphatasia, Mild HPPA Hypophosphatasia Mild Hypophosphatasia Adult Rathbun Disease Adult Phosphoethanolaminuria HOPS
Osteomalacia	Adult Rickets
Uremia	Uremia Of Renal Origin
Enthesopathy	Rheumatism
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Angioid Streaks
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Hypophosphatemic Rickets With Hypercalciuria, Hereditary	Hereditary Hypophosphatemic Rickets With Hypercalciuria HHRH Hypophosphatemic Rickets With Hypercalciuria Hypercalciuric Rickets
Hypophosphatemic Rickets, Autosomal Dominant	Autosomal Dominant Hypophosphatemic Rickets ADHR Autosomal Dominant Hypophosphatemia Vitamin D-Resistant Rickets, Autosomal Dominant Hypophosphatemia, Autosomal Dominant Autosomal Dominant Vitamin D-Resistant Rickets Rickets, Hypophosphatemic, Autosomal Dominant
Osteoglophonic Dysplasia	Osteoglophonic Dwarfism OGD Fairbank-Keats Syndrome Osteoglosphonic Dysplasia Dysplasia, Osteoglophonic
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Hypophosphatemic Rickets, X-Linked Dominant	X-Linked Hypophosphatemia Xlh Vitamin D-Resistant Rickets, X-Linked X-Linked Hypophosphatemic Rickets XLHR Hyp Hypophosphatemic Vitamin D-Resistant Rickets Hpdr X-Linked Dominant Hypophosphatemic Rickets Familial Hypophosphatemic Rickets Hypophosphatemia, X-Linked Hypophosphatemia, Vitamin D-Resistant Rickets Hypophosphatemic Rickets X-Linked Dominant X-Linked Vitamin D-Resistant Rickets Hypophophatemia, X-Linked Hypophophatemic Vitamin D-Resistant Rickets Hypophosphatemia X-Linked Vitamin D-Resistant Rickets X-Linked Vitamin D-Resistant Rickets Rickets, X-Linked Hypophosphatemic
Hypophosphatasia, Childhood	Childhood Hypophosphatasia Childhood-Onset Hypophosphatasia HPPC Childhood-Onset Phosphoethanolaminuria Childhood-Onset Rathburn Disease Childhood-Onset Rathbun Disease
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1	Hypophosphatemic Nephrolithiasis/Osteoporosis 1 NPHLOP1 Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1 Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1
Schimmelpenning-Feuerstein-Mims Syndrome	Nevus Sebaceus Of Jadassohn Organoid Nevus Phakomatosis Linear Nevus Sebaceous Syndrome Sfm Syndrome Jadassohn Nevus Phakomatosis Jnp Schimmelpenning Syndrome Solomon Syndrome SFM Linear Sebaceous Nevus Syndrome Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic Nevus Sebaceus Syndrome Organoid Nevus Syndrome Schimmelpenning Feuerstein Mims Syndrome Sebaceous Nevus Syndrome, Linear Epidermal Nevus Syndrome, Formerly Sebaceous Nevus Syndrome Linear Linear Nevus Sebaceus Syndrome Epidermal Nevus Syndrome Ss Nevus Sebaceous
Dental Abscess
Ankylosis
Tooth Ankylosis	Ankylosis Of Teeth Ankylosis Of Tooth
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Diffuse Idiopathic Skeletal Hyperostosis	Hyperostosis, Diffuse Idiopathic Skeletal Ankylosing Vertebral Hyperostosis Dish Disseminated Idiopathic Skeletal Hyperostosis Forestier Disease Forestier'S Disease Hyperostosis Diffuse Idiopathic Skeletal
Vitamin D-Dependent Rickets	Vddr
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Polycystic Liver Disease 1 PCLD1 Cyst Liver Disease, Polycystic, Type 1 Polycystic Liver Disease
Metaphyseal Chondrodysplasia, Jansen Type	Metaphyseal Chondrodysplasia, Murk Jansen Type Jansen'S Metaphyseal Chondrodysplasia MCDJ Murk Jansen Type Metaphyseal Chondrodysplasia Jansen Type Metaphyseal Chondrodysplasia Jansen Disease Jansen Metaphyseal Chondrodysplasia Jansen Metaphyseal Dysostosis Metaphyseal Chondrodysplasia Murk Jansen Type Chondrodysplasia, Metaphyseal, Murk Jansen Type
Hypophosphatemic Nephrolithiasis/Osteoporosis	Nephrolithiasis/Osteoporosis, Hypophosphatemic
Tumoral Calcinosis, Normophosphatemic, Familial	Normophosphatemic Familial Tumoral Calcinosis NFTC Tumoral Calcinosis, Familial, Normophosphatemic Calcinosis, Tumoral, With Normophosphatemia Familial Normophosphatemic Tumoral Calcinosis Tumoral Calcinosis With Normophosphatemia
Vitamin D Hydroxylation-Deficient Rickets, Type 1b	VDDR1B Vitamin D-Dependent Rickets Type 1b Vitamin D-Dependent Rickets, Type 1b 25-Hydroxyvitamin D3 Deficiency, Selective Pseudovitamin D3 Deficiency Rickets Due To 25-Hydroxylase Deficiency Rickets Due To Defect In Vitamin D 25-Hydroxylation Deficiency Rickets Vitamin D-Dependent 1b 25-Hydroxyvitamimn D3 Deficiency Selective 25-Hydroxyvitamin D(3) Deficiency Pseudovitamin D(3) Deficiency Rickets Due To 25-Hydroxylase Deficiency Selective 25-Hydroxyvitamin D(3) Deficiency Rickets Due To Defect In Vitamin D 25-Hydroxylation
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1	Hyperphosphatemic Familial Tumoral Calcinosis Hftc Hyperostosis-Hyperphosphatemia Syndrome Familial Hyperphosphatemic Tumoral Calcinosis/Hyperphosphatemic Hyperostosis Syndrome Tumoral Calcinosis, Hyperphosphatemic, Familial Phptc Lipocalcinogranulomatosis Morbus Teutschlaender Hhs Hyperostosis With Hyperphosphatemia Cortical Hyperostosis With Hyperphosphatemia Primary Hyperphosphatemic Tumoral Calcinosis Familial Tumoral Calcinosis HFTC1 Hypercalcemic Tumoral Calcinosis Hyperphosphatemia Hyperostosis Hyperphosphatemia Hyperostosis Syndrome Hyperphosphatemia Tumoral Calcinosis Tumoral Calcinosis Calcinosis, Tumoral, With Hyperphosphatemia Tumoral Calcinosis, Primary Hyperphosphatemic Teutschlaender Disease, Familial Familial Teutschlaender Disease Tumoral Calcinosis With Hyperphosphatemia Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome Ftc/Hhs Familial Tumoral Calcinosis With Hyperphosphatemia Teutschlaender Disease Tumoral Calcinosis Primary Hyperphosphatemic Calcinosis, Tumoral, Hyperphosphatemic, Familial
Vitamin D-Dependent Rickets, Type 2a	Hvdrr Generalized Resistance To 1,25-Dihydroxyvitamin D Hypocalcemic Vitamin D-Resistant Rickets VDDR2A Rickets, Hereditary Vitamin D-Resistant Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol Pddr Iia Rickets-Alopecia Syndrome Rickets, Vitamin D-Resistant, Type Iia Vitamin D-Dependent Rickets Type 2a Vitamin D-Dependent Rickets, Type 2 Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia Generalized 1,25-Dihydroxyvitamin D Pseudovitamin D-Deficiency, Type Iia Hereditary Vitamin D-Resistant Rickets Vddr Ii Vdrr Ii Vitamin D-Dependent Rickets Type Ii Vitamin D-Resistant Rickets Type Ii Rickets Vitamin D-Dependent 2a Pseudovitamin D-Deficiency Type Iia Rickets Hereditary Vitamin D-Resistant Type Iia Rickets Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia Vitamin D-Dependent Rickets, Type Ii Familial Hypophosphatemic Rickets Hypophosphatemic Rickets, X-Linked Dominant
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Fanconi Syndrome	Infantile Nephropathic Cystinosis Adult Fanconi Syndrome Congenital Fanconi Syndrome De Toni-Fanconi Syndrome Fanconi-De Toni Syndrome Lignac-Fanconi Syndrome Fanconi Renotubular Syndrome Primary Fanconi Renotubular Syndrome De Toni-Debre-Fanconi Syndrome Adult Fanconi Anemia Detoni Fanconi Syndrome Fanconi-De-Toni Syndrome Primary Fanconi Syndrome Detoni-Debre-Fanconi Syndrome Primary Fanconi Renal Syndrome Fanconi Anemia Cystinosis, Infantile Nephropathic Fanconi-Bickel Syndrome Renal Fanconi Syndrome Lowe-Bickel Syndrome
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-176708	ISM5939	Inhibitor	99.79%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991677	Efmirenpase alfa		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129490	Enpp-1-IN-1	Inhibitor	99.19%	Unkown
HY-147389	Enpp-1-IN-14	Inhibitor	99.67%	Unkown
HY-139362	Enpp-1-IN-2	Inhibitor	99.51%	Unkown
HY-143256	Enpp-1-IN-12	Inhibitor	99.28%	Unkown
HY-141831	STF-1084	Inhibitor	99.92%	Unkown
HY-155457	Enpp-1-IN-19		99.28%	Unkown
HY-169804	ENPP3 Inhibitor 1	Inhibitor	99.43%	Unkown
HY-158791	Enpp-1-IN-21	Inhibitor	99.07%	Unkown
HY-153335	Enpp-1-IN-16	Inhibitor	98.46%	Unkown
HY-163343	Enpp-1-IN-20		98.06%	Unkown
HY-176296	Vizenpistat	Inhibitor	99.14%	Unkown
HY-143254	Enpp-1-IN-10	Inhibitor	98.64%	Unkown
HY-149465	STF-1623		99.90%	Unkown
HY-145063	Enpp-1-IN-5	Inhibitor	98.16%	Unkown
HY-153398	Enpp-1-IN-17	Inhibitor	99.65%	Unkown
HY-173189	2-5A	Inhibitor	/	Unkown
HY-143255	Enpp-1-IN-11	Inhibitor	/	Unkown
HY-145062	Enpp-1-IN-4	Inhibitor	/	Unkown
HY-145064	Enpp-1-IN-6	Inhibitor	/	Unkown
HY-145065	Enpp-1-IN-7	Inhibitor	/	Unkown
HY-145069	Enpp-1-IN-8	Inhibitor	/	Unkown
HY-145070	Enpp-1-IN-9	Inhibitor	/	Unkown
HY-147998	Enpp-1-IN-13	Inhibitor	/	Unkown
HY-153334	Enpp-1-IN-15	Inhibitor	/	Unkown
HY-157522	NCI-14465	Inhibitor	/	Unkown
HY-162911	Enpp-1-IN-22	Inhibitor	/	Unkown
HY-162912	Enpp-1-IN-23	Inhibitor	/	Unkown
HY-168147	Enpp-1-IN-24	Inhibitor	/	Unkown
HY-168491	Enpp-1-IN-25		/	Unkown
HY-172527	CD73-IN-20	Inhibitor	/	Unkown
HY-172528	Enpp-1/3-IN-1	Inhibitor	/	Unkown
HY-175047	Enpp-1-IN-26	Inhibitor	/	Unkown
HY-175478	Enpp-1-IN-27		/	Unkown
HY-176828	Enpp-1-IN-28	Inhibitor	/	Unkown
HY-176874	Enpp-1-IN-29	Inhibitor	/	Unkown
HY-181667	Enpp-1-IN-30	Inhibitor	/	Unkown
HY-182772	Enpp-1-IN-31	Inhibitor	/	Unkown
HY-184200	Enpp-1-IN-32		/	Unkown
HY-RS04387	ENPP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156205	CdnP-IN-1	Inhibitor	/	Unkown
HY-RS16545	Enpp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22977	Enpp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENPP1	VGNC	VGNC:28504
Rattus norvegicus	ENPP1	RGD	RGD:628825
Macaca mulatta	ENPP1	VGNC	VGNC:72222
Canis familiaris	ENPP1	VGNC	VGNC:40374
Mus musculus	ENPP1	MGD	MGI:97370
Felis catus	ENPP1	VGNC	VGNC:61872
Others	ENPP1	NCBI