S1pr5 - sphingosine-1-phosphate receptor 5 Gene

Mus musculus

Also known as Edg8; S1P5; lpB4

Gene ID: 94226 | Gene type: protein coding

About S1pr5

Chromosome 9: 21,154,208-21,159,739 reverse strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 236 orthologues, 18 paralogues and is associated with 5 phenotypes. Biased expression in cerebellum adult (RPKM 1.8), stomach adult (RPKM 9.4) and 11 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genital tubercle; liver; sensory organ; and unsegmented mesenchyme. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

S1pr5 Products(1)

mRNA	Protein	Name
NM_053190.2	NP_444420.1	sphingosine 1-phosphate receptor 5

S1pr5 Protein Structure

7tm_GPCRs

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 5

S1P receptor 5	S1P receptor Edg-8
endothelial differentiation G-protein-coupled receptor 8	endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
lysophospholipid receptor B4	sphingosine 1-phosphate receptor Edg-8
sphingosine-1-phosphate receptor LPB4

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	98.88%	Yes
HY-12288	Ozanimod	Agonist	99.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12288A	Ozanimod hydrochloride	Modulator	99.19%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136578	RP101988	Agonist	98.92%	Unkown
HY-111253	CYM-5478	Agonist	/	Unkown
HY-148198	S1P5 receptor agonist-1	Agonist	/	Unkown
HY-136576	RP101075	Agonist	/	Unkown
HY-148115	S1p receptor agonist 2	Agonist	/	Unkown
HY-136577	RP101442	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr5	NCBI	NCBI:53637

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