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Cat. No.: HY-N9348

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Glucoraphenin

Glucoraphenin is an orally effective glucosinolate. Glucoraphenin can be isolated from radish sprouts. Glucoraphenin enhances the enzymatic activity of Glutathione S-transferase. Glucoraphenin enhances the activity of cytochrome P450-related monooxygenase.

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CAS No.: 28463-24-3
화학식: C₁₂H₂₁NO₁₀S₃
분자량:435.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Glucoraphenin Chemical Structure

CAS No.: 28463-24-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

XME^[2]

All Cytochrome P450 Isoforms :

In Vivo

Glucoraphenin (24-120 mg/kg; p.o.; single dose; daily for four consecutive days) modulates hepatic xenobiotic metabolizing enzymes in male Sprague Dawley rats, with the single 24 mg/kg oral dose producing the strongest inductive effects, including a 3.2-fold increase in glutathione S-transferase activity and a 2-fold increase in CYP1A2-linked methoxyresorufin O-demethylase activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 280 g)^[1]
Dosage:

24 mg/kg (single dose; repeated daily for four days); 120 mg/kg (single dose; repeated daily for four days)
Administration:

p.o.; single dose; daily for four consecutive days
Result:

Increased CYP3A1/2-linked aminopyrine N-demethylase activity to 9.67 nmol mg^-1 min^-1 (single 24 mg/kg), 9.67 nmol mg^-1 min^-1 (single 120 mg/kg), 7.11 nmol mg^-1 min^-1 (repeated 24 mg/kg), and 7.22 nmol mg^-1 min^-1 (repeated 120 mg/kg) from control 5.50 nmol mg^-1 min^-1.
Increased CYP1A2-linked methoxyresorufin O-demethylase activity to 20.67 pmol mg^-1 min^-1 (single 24 mg/kg) and 17.90 pmol mg^-1 min^-1 (repeated 24 mg/kg) from control 10.33 pmol mg^-1 min^-1; slightly increased it to 11.71 pmol mg^-1 min^-1 (single 120 mg/kg), while repeated 120 mg/kg showed no significant change.
Showed no significant changes in CYP1A1-linked ethoxyresorufin O-deethylase activity across any dose or schedule compared to control 33.34 pmol mg^-1 min^-1.

Chemical Information

CAS No. 28463-24-3
분자량 435.48
화학식 C₁₂H₂₁NO₁₀S₃
SMILES

S(C(CCC=CS(C)=O)=NOS(=O)(=O)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Structure Classification
- Glucosinolates
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Barillari J, et al. Glucoraphasatin and glucoraphenin, a redox pair of glucosinolates of brassicaceae, differently affect metabolizing enzymes in rats. J Agric Food Chem. 2007;55(14):5505-5511. [Content Brief]

[2]. Li R, et al. Glucoraphenin, sulforaphene, and antiproliferative capacity of radish sprouts in germinating and thermal processes[J]. European Food Research and Technology, 2017, 243(4): 547-554.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
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Glucoraphenin

All Cytochrome P450 Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vivo

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Glucoraphenin Related Classifications

HY-N9348 Related Classifications

Bioz

Keywords

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