2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. GRL093-22

GRL093-22 is a potent and selective G protein-coupled receptor kinase (GRK) inhibitor, with IC50s of 60 and 40 nM for GRK5 and GRK6, respectively. GRL093-22 has the potential for the research of heart failure and multiple myeloma.

For research use only. We do not sell to patients.

GRL093-22

GRL093-22 Chemical Structure

CAS No. : 3113391-19-5

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Based on 1 publication(s) in Google Scholar

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Description

GRL093-22 is a potent and selective G protein-coupled receptor kinase (GRK) inhibitor, with IC50s of 60 and 40 nM for GRK5 and GRK6, respectively. GRL093-22 has the potential for the research of heart failure and multiple myeloma[1].

Molecular Weight

576.62

Formula

C33H29FN6O3
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

FC1=CC=C([C@H](NC(C2=CC=C(NC(/C3=C\C4=C(C)C(NC(C5=C(C)N=C6N5C=CC=C6)=O)=C(C)N4)=O)C3=C2)=O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (43.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7342 mL 8.6712 mL 17.3424 mL
5 mM 0.3468 mL 1.7342 mL 3.4685 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7342 mL 8.6712 mL 17.3424 mL 43.3561 mL
5 mM 0.3468 mL 1.7342 mL 3.4685 mL 8.6712 mL
10 mM 0.1734 mL 0.8671 mL 1.7342 mL 4.3356 mL
15 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8904 mL
20 mM 0.0867 mL 0.4336 mL 0.8671 mL 2.1678 mL
25 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
30 mM 0.0578 mL 0.2890 mL 0.5781 mL 1.4452 mL
40 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0839 mL
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GRL093-22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRL093-223113391-19-5G Protein-coupled Receptor Kinase (GRK)heart failuremultiple myelomaInhibitorinhibitorinhibit

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