GS-443902 trisodium
Based on 13 publication(s) in Google Scholar
GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).
For research use only. We do not sell to patients.
- Purity : 99.94%
- CAS No.: 1355050-21-3
- Formula: C12H13N5Na3O13P3
- Molecular Weight:597.15
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Storage:
-80°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) GS-443902 trisodium
More- Cell. 2022 Nov 10;185(23):4347-4360.e17. [Abstract]
- Nat Commun. 2021 Oct 4;12(1):5811. [Abstract]
- Acta Pharm Sin B. 2021 Jun;11(6):1607-1616. [Abstract]
- J Control Release. 2025 Nov 10:387:114245. [Abstract]
- EMBO J. 2025 Jan;44(2):563-586. [Abstract]
- J Med Chem. 2025 Jun 26;68(12):12414-12433. [Abstract]
- J Med Chem. 2024 May 9;67(9):7470-7486. [Abstract]
- Int J Mol Sci. 2022 Jul 27;23(15):8302. [Abstract]
- Chem Biol Interact. 2021 Jul 1:343:109480. [Abstract]
- Sci Rep. 2022 Nov 2;12(1):18506. [Abstract]
- Research Square Preprint. 2022 May.
- Curr Res Pharmacol Drug Discov. 2021:2:100045. [Abstract]
- bioRxiv. 2021 Jul 21:2021.07.21.453274. [Abstract]
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Description
IC50 & Target
In Vitro
In a continuous 72 h incubation of 1 μM Remdesivir (GS-5734), the GS-443902 trisodium (GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium) level is measured at 2, 24, 48 and 72 h, and reaches a Cmax of 300, 110, and 90 pmol/million cells in macrophages, HMVEC, and HeLa cells lines respectively[1].
GS-443902 trisodium (compound 8a) is a triphosphates (TP) derivative[2].
GS-443902 trisodium (NTP; 0.01, 0.1, 1, 10, 100 μM) inhibits RSV RdRp-catalysed RNA synthesis by incorporating into the nascent viral RNA transcript and causing its premature termination. GS-5734 selectively inhibits EBOV replication by targeting its RdRp and inhibiting viral RNA synthesis following efficient intracellular conversion to GS-443902 sodium[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1355050-21-3
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Appearance Solid
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Molecular Weight 597.15
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Formula C12H13N5Na3O13P3
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Color White to light yellow
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SMILES
O=P(OP(O)(O[Na])=O)(O[Na])OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O[Na])=O
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Synonyms
GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (13)
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Journal Impact Factor
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Most Recent
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Cell
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. [Abstract]2022 Nov 10;185(23):4347-4360.e17. PMID: 36335936 -
Nat Commun
2021 Oct 4;12(1):5811. PMID: 34608151 -
Acta Pharm Sin B
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment. [Abstract]2021 Jun;11(6):1607-1616. PMID: 34221871 -
J Control Release
A general nanoplatform for nucleotide drug delivery: From molecular binding to antiviral therapy. [Abstract]2025 Nov 10:387:114245. PMID: 40975176 -
EMBO J
2025 Jan;44(2):563-586. PMID: 39739115 -
J Med Chem
Identification of 4'-Thiouridine as an Orally Available Antiviral Agent Targeting Both RdRp and NiRAN Functions of SARS-CoV-2 Nsp12. [Abstract]2025 Jun 26;68(12):12414-12433. PMID: 40512093 -
J Med Chem
Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung. [Abstract]2024 May 9;67(9):7470-7486. PMID: 38690769 -
Int J Mol Sci
A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA Polymerase. [Abstract]2022 Jul 27;23(15):8302. PMID: 35955442 -
Chem Biol Interact
2021 Jul 1:343:109480. PMID: 33887223 -
Sci Rep
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells. [Abstract]2022 Nov 2;12(1):18506. PMID: 36323770 -
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Curr Res Pharmacol Drug Discov
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside. [Abstract]2021:2:100045. PMID: 34870151 -
bioRxiv
Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics. [Abstract]2021 Jul 21:2021.07.21.453274. PMID: 34312622
Solvent & Solubility
In Vitro:
H2O : 33.33 mg/mL (55.82 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (83.73 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. [Content Brief]
[2]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. [Content Brief]
[3]. Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6746 mL | 8.3731 mL | 16.7462 mL | 41.8655 mL |
| 5 mM | 0.3349 mL | 1.6746 mL | 3.3492 mL | 8.3731 mL | |
| 10 mM | 0.1675 mL | 0.8373 mL | 1.6746 mL | 4.1866 mL | |
| 15 mM | 0.1116 mL | 0.5582 mL | 1.1164 mL | 2.7910 mL | |
| 20 mM | 0.0837 mL | 0.4187 mL | 0.8373 mL | 2.0933 mL | |
| 25 mM | 0.0670 mL | 0.3349 mL | 0.6698 mL | 1.6746 mL | |
| 30 mM | 0.0558 mL | 0.2791 mL | 0.5582 mL | 1.3955 mL | |
| 40 mM | 0.0419 mL | 0.2093 mL | 0.4187 mL | 1.0466 mL | |
| 50 mM | 0.0335 mL | 0.1675 mL | 0.3349 mL | 0.8373 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
GS-443902 trisodium Related Classifications
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