2. Anti-infection Metabolic Enzyme/Protease
  3. HIV HIV Integrase
  4. GSK-364735

GSK-364735 is a potent antiretroviral agent against human immunodeficiency virus type 1 (HIV-1) and serves as an integrase inhibitor with an IC50 of 8 ± 2 nM. GSK-364735 can be utilized in antiviral research.

For research use only. We do not sell to patients.

GSK-364735

GSK-364735 Chemical Structure

CAS No. : 863434-13-3

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Based on 1 publication(s) in Google Scholar

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Description

GSK-364735 is a potent antiretroviral agent against human immunodeficiency virus type 1 (HIV-1) and serves as an integrase inhibitor with an IC50 of 8 ± 2 nM. GSK-364735 can be utilized in antiviral research[1].

Cellular Effect
Cell Line Type Value Description References
MT4 EC50
1.7 nM
Compound: GSK-364735
Antiviral activity against vesicular stomatitis virus G-pseudotyped Human immunodeficiency virus infected in human MT-4 cells assessed as inhibition of viral replication
Antiviral activity against vesicular stomatitis virus G-pseudotyped Human immunodeficiency virus infected in human MT-4 cells assessed as inhibition of viral replication
[PMID: 18160521]
MT4 EC50
5 nM
Compound: GSK-364735
Antiviral activity against Human immunodeficiency virus 1 3B infected in human MT-4 cells assessed as inhibition of viral replication
Antiviral activity against Human immunodeficiency virus 1 3B infected in human MT-4 cells assessed as inhibition of viral replication
[PMID: 18160521]
MT4 IC50
0.005 μM
Compound: 32
Antiviral activity against HIV infected in human MT4 cells
Antiviral activity against HIV infected in human MT4 cells
[PMID: 23245515]
Molecular Weight

371.36

Formula

C19H18FN3O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=C(O)C2=NC=C(CC3=CC=C(F)C=C3)C=C2N(C)C1=O)NCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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GSK-364735 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-364735863434-13-3S/GSK-364735GSK364735GSK 364735HIVHIV IntegraseHuman immunodeficiency virusHIV-1integraseantiviralInhibitorinhibitorinhibit

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HY-16907
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