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Cat. No.: HY-11003R

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GW843682X (Standard)

Name: GW843682X (Standard)
Brand: MedChemExpress
SKU: HY-11003R
Availability: PreOrder

(Synonyms: GW843682 (Standard))

GW843682X (Standard) is the analytical standard of GW843682X (HY-11003). This product is intended for research and analytical applications. GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC₅₀s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ～30 other K_inases.

For research use only. We do not sell to patients.

CAS No.: 660868-91-7
Formula: C₂₂H₁₈F₃N₃O₄S
Molecular Weight:477.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GW843682X (Standard) Chemical Structure

CAS No.: 660868-91-7

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 660868-91-7
Molecular Weight 477.46
Formula C₂₂H₁₈F₃N₃O₄S
SMILES

O=C(C1=C(OCC2=CC=CC=C2C(F)(F)F)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N
Synonyms

GW843682 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31. [Content Brief]

[2]. Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591(1-3):102-5. [Content Brief]

[3]. Ikezoe T, et al. A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23(9):1564-76. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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