GYKI-47261

Cat. No.: HY-19435: Data Sheet Handling Instructions
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GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC₅₀ of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1.

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GYKI-47261 화학구조

CAS No. : 220445-20-5

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

Other Forms of GYKI-47261:

GYKI-47261 dihydrochloride 견적 받기

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•Related Small Molecules:

•Related Proteins:

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AMPA Receptor NMDA Receptor Kainate Receptor

View All Cytochrome P450 Isoform Specific Products:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

GYKI-47261 (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice^[1].
GYKI-47261(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57 black mice, weighing 23-30 g^[1]
Dosage:	20 mg/kg
Administration:	I.p.
Result:	Reversed the MPTP-induced decrease in striatal concentrations.

분자량

322.79

화학식

C₁₈H₁₅ClN₄

CAS No.

220445-20-5

SMILES

NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Abrahám G, et al. New non competitive AMPA antagonists. Bioorg Med Chem. 2000;8(8):2127-2143. [Content Brief]

[2]. Tamási V, et al. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug Metab Dispos. 2003;31(11):1310-1314. [Content Brief]

GYKI-47261 Related Classifications

Neurological Disease

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농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GYKI-47261220445-20-5GYKI47261GYKI 47261iGluRCytochrome P450Ionotropic glutamate receptorsCYPsneurotoxicityParkinsonsdiseaseantiischemiceanticonvulsivecompetitiveInhibitorinhibitorinhibit

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