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Cat. No.: HY-183320

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HDAC6-IN-81

HDAC6-IN-81 is a potent selective HDAC6 inhibitor with an IC₅₀of 1 nM. HDAC6-IN-81 exhibits selectivity over class I HDAC isoforms (HDAC1/2/3/8). HDAC6-IN-81 can be used for the research of cancer.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₃N₅O₆
Molecular Weight:559.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6-IN-81 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

HDAC1

20 nM (IC₅₀)

HDAC6

1 nM (IC₅₀)

All HDAC Isoforms :

In Vitro

HDAC6-IN-81 (compound 18) (10 μM) potently inhibits purified HDAC1 (IC₅₀ = 20 nM) and HDAC6 (IC₅₀ = 1 nM) with a 20-fold preferential activity for HDAC6 over HDAC1^[1].
HDAC6-IN-81 (10 nM) preferentially inhibits purified HDAC6 (81% inhibition) over purified class I HDAC isoforms HDAC1 (33% inhibition), HDAC2 (34% inhibition), HDAC3 (50% inhibition), and HDAC8 (4% inhibition)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 559.61
Formula C₃₀H₃₃N₅O₆
SMILES

O=C(NC1=CC=C(N(CCCCCC(NO)=O)C=C2C(NC3=CC=C(OC)C=C3)=O)C2=C1)NC4=CC=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shawky S, et al. Towards the discovery of potent epigenetic modulators: Design, synthesis, biological evaluation, and SAR investigation of novel indole-based derivatives targeting HDAC1 and HDAC6. Bioorg Chem. 2026;175:109772. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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