HDAC6-IN-81
HDAC6-IN-81 is a potent selective HDAC6 inhibitor with an IC50 of 1 nM. HDAC6-IN-81 exhibits selectivity over class I HDAC isoforms (HDAC1/2/3/8). HDAC6-IN-81 can be used for the research of cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C30H33N5O6
- Peso molecular:559.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
HDAC1 20 nM (IC50) |
HDAC6 1 nM (IC50) |
In Vitro
HDAC6-IN-81 (compound 18) (10 μM) potently inhibits purified HDAC1 (IC50 = 20 nM) and HDAC6 (IC50 = 1 nM) with a 20-fold preferential activity for HDAC6 over HDAC1[1].
HDAC6-IN-81 (10 nM) preferentially inhibits purified HDAC6 (81% inhibition) over purified class I HDAC isoforms HDAC1 (33% inhibition), HDAC2 (34% inhibition), HDAC3 (50% inhibition), and HDAC8 (4% inhibition)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 559.61
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Fòrmula C30H33N5O6
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SMILES
O=C(NC1=CC=C(N(CCCCCC(NO)=O)C=C2C(NC3=CC=C(OC)C=C3)=O)C2=C1)NC4=CC=C(OC)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-81 Related Classifications
HY-183320 Related Classifications
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