2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-81

HDAC6-IN-81 is a potent selective HDAC6 inhibitor with an IC50 of 1 nM. HDAC6-IN-81 exhibits selectivity over class I HDAC isoforms (HDAC1/2/3/8). HDAC6-IN-81 can be used for the research of cancer.

For research use only. We do not sell to patients.

HDAC6-IN-81

HDAC6-IN-81 Chemical Structure

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HDAC6-IN-81 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6-IN-81 is a potent selective HDAC6 inhibitor with an IC50 of 1 nM. HDAC6-IN-81 exhibits selectivity over class I HDAC isoforms (HDAC1/2/3/8). HDAC6-IN-81 can be used for the research of cancer[1].

IC50 & Target[1]

HDAC1

20 nM (IC50)

HDAC6

1 nM (IC50)

In Vitro

HDAC6-IN-81 (compound 18) (10 μM) potently inhibits purified HDAC1 (IC50 = 20 nM) and HDAC6 (IC50 = 1 nM) with a 20-fold preferential activity for HDAC6 over HDAC1[1].
HDAC6-IN-81 (10 nM) preferentially inhibits purified HDAC6 (81% inhibition) over purified class I HDAC isoforms HDAC1 (33% inhibition), HDAC2 (34% inhibition), HDAC3 (50% inhibition), and HDAC8 (4% inhibition)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-81 Related Antibodies
Molecular Weight

559.61

Formula

C30H33N5O6
SMILES

O=C(NC1=CC=C(N(CCCCCC(NO)=O)C=C2C(NC3=CC=C(OC)C=C3)=O)C2=C1)NC4=CC=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-81 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-81HDACHistone deacetylasesleukemiacolon cancernon-small cell lung cancerHDAC6HDAC1cns cancermelanomabreast cancerovarian cancerrenal cancerInhibitorinhibitorinhibit

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HDAC6-IN-81
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HY-183320
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