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Referencia número: HY-183320

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HDAC6-IN-81

HDAC6-IN-81 is a potent selective HDAC6 inhibitor with an IC₅₀of 1 nM. HDAC6-IN-81 exhibits selectivity over class I HDAC isoforms (HDAC1/2/3/8). HDAC6-IN-81 can be used for the research of cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₀H₃₃N₅O₆
Peso molecular:559.61

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6-IN-81 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

HDAC1

20 nM (IC₅₀)

HDAC6

1 nM (IC₅₀)

Ver todos los productos específicos de isoformas HDAC :

In Vitro

HDAC6-IN-81 (compound 18) (10 μM) potently inhibits purified HDAC1 (IC₅₀ = 20 nM) and HDAC6 (IC₅₀ = 1 nM) with a 20-fold preferential activity for HDAC6 over HDAC1^[1].
HDAC6-IN-81 (10 nM) preferentially inhibits purified HDAC6 (81% inhibition) over purified class I HDAC isoforms HDAC1 (33% inhibition), HDAC2 (34% inhibition), HDAC3 (50% inhibition), and HDAC8 (4% inhibition)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Peso molecular 559.61
Fòrmula C₃₀H₃₃N₅O₆
SMILES

O=C(NC1=CC=C(N(CCCCCC(NO)=O)C=C2C(NC3=CC=C(OC)C=C3)=O)C2=C1)NC4=CC=C(OC)C=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Shawky S, et al. Towards the discovery of potent epigenetic modulators: Design, synthesis, biological evaluation, and SAR investigation of novel indole-based derivatives targeting HDAC1 and HDAC6. Bioorg Chem. 2026;175:109772. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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