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Cat. No.: HY-179228

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AN02

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer.

For research use only. We do not sell to patients.

CAS No.: 1246964-08-8
Formula: C₁₉H₁₅Cl₂NO
Molecular Weight:344.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AN02 Chemical Structure

CAS No.: 1246964-08-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

All TGF-beta/Smad Isoforms :

Smad1
Smad3

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-231	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-231	IC₅₀	1.6 μM Compound: A2	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay	[PMID: 38746900]
MDA-MB-468	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MG-63	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MV4-11	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H23	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H441	IC₅₀	5 μM Compound: 3	Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs	[PMID: 20638855]

Chemical Information

CAS No. 1246964-08-8
Molecular Weight 344.23
Formula C₁₉H₁₅Cl₂NO
SMILES

ClC1=CC=CC=C1/C=C(C/2=O)\CNCC2=C/C3=C(Cl)C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin H, et al. AN02, a Naovel Curcumin Derivative, Orchestrates APC-SMAD4-Mediated CTLA-4 Degradation for Ovarian Cancer Therapy. Mol Carcinog. 2025 Oct 21. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
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References

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AN02

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AN02 Related Classifications

HY-179228 Related Classifications