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Cat. No.: HY-134192

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TH301

TH301 is a Phenylpyrazole derivative. TH301 selectively stabilize CRY2. TH301 dose-dependently prolongs circadian period.

For research use only. We do not sell to patients.

CAS No.: 450338-32-6
Formula: C₂₄H₂₄ClN₃O₄S
Molecular Weight:485.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TH301 Chemical Structure

CAS No.: 450338-32-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TH301 is a Phenylpyrazole derivative. TH301 selectively stabilize CRY2. TH301 dose-dependently prolongs circadian period^[1].

IC₅₀ & Target^[1]

CRY2

All Cryptochrome Isoforms :

CRY1
CRY2

Chemical Information

CAS No. 450338-32-6
Molecular Weight 485.98
Formula C₂₄H₂₄ClN₃O₄S
SMILES

O=C(C1(C2=CC=C(Cl)C=C2)CCCC1)NC3=C4C(CS(C4)(=O)=O)=NN3C5=CC=C(OC)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miller S, et al. Isoform-selective regulation of mammalian cryptochromes. Nat Chem Biol. 2020 Jun;16(6):676-685. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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TH301

All Cryptochrome Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TH301 Related Classifications

HY-134192 Related Classifications