Human UGT1A10
Human UGT1A10 is a UDP-glucuronosyltransferase. UGT1A10 catalyzes the glucuronidation of Mycophenolic acid (HY-B0421). Human UGT1A10 mediates glucuronidation modification of 34 out of 42 tested bioflavonoids. Human UGT1A10 is applicable to relevant research on colorectal cancer.
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Activité biologique
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UGT1A10 |
When expressed in COS-7 cells, UGT1A10 (30 min) efficiently glucuronidates Mycophenolic acid (HY-B0421), with an apparent Km value of 34 μM and a Vmax value of 0.63 nmole/min/mg protein, producing multiple glucuronide products[1].
His-tagged UGT1A10 (UGT1A10-H) exhibits high glucuronidation activity towards 9 different substrates[2].
Human UGT1A10 can glucuronidate 34 out of the 42 tested bioflavonoids, with a typical activity range of 3 to 14 nmol min-1 mg-1 protein. This enzyme exhibits preferential activity toward substrates with hydroxyl groups at specific ring positions, while showing reduced or no activity toward glycosylated substrates[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Human UGT1A10]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Mojarrabi B, et al. The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid. Biochemical and biophysical research communications. 1997 Sep 29;238(3):775-8. [Content Brief]
[2]. Troberg J, et al. UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?. Molecular pharmaceutics. 2017 Sep 05;14(9):2875-2883. [Content Brief]
[3]. Lewinsky RH, et al. Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships. Xenobiotica; the fate of foreign compounds in biological systems. 2005 Feb;35(2):117-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human UGT1A10 Related Classifications
HY-E72112 Related Classifications
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