Hyrtiosal
Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents.
For research use only. We do not sell to patients.
- CAS No.: 138355-07-4
- Formula: C25H38O3
- Molecular Weight:386.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
18 μM
Compound: 5
|
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
|
[PMID: 19788270] |
| HuCC-A1 | IC50 |
9.1 μM
Compound: 5
|
Cytotoxicity against human HuCCa1 cells
Cytotoxicity against human HuCCa1 cells
|
[PMID: 19788270] |
| KB | IC50 |
7.8 μM
Compound: 5
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 19788270] |
| MDA-MB-231 | IC50 |
5.4 μM
Compound: 5
|
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
|
[PMID: 19788270] |
| NCI-H69 | IC50 |
31 μM
Compound: 5
|
Cytotoxicity against human adriamycin resistant H69 cells
Cytotoxicity against human adriamycin resistant H69 cells
|
[PMID: 19788270] |
| T47D | IC50 |
9.1 μM
Compound: 5
|
Cytotoxicity against human T47D cells
Cytotoxicity against human T47D cells
|
[PMID: 19788270] |
Chemical Information
-
CAS No. 138355-07-4
-
Molecular Weight 386.57
-
Formula C25H38O3
-
SMILES
C[C@]12[C@@](C[C@@](C)([C@H]2C[C@@H](C3=COC=C3)O)C=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C
-
Structure Classification
-
Initial Source
marine sponge Hyrtios erectus
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)