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PP2

(Synonyms: AGL 1879)
64 Cited Publications
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Based on 64 publication(s) in Google Scholar

PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.14%
  • CAS No.: 172889-27-9
  • Formula: C15H16ClN5
  • Molecular Weight:301.77
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • PP2 Chemical Structure
    PP2 Chemical Structure
  • Experimental Validation Results for PP2
  • Experimental Validation Results for PP2
  • Experimental Validation Results for PP2
  • Experimental Validation Results for PP2
  • Experimental Validation Results for PP2
CAS No.: 172889-27-9
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  • PP2 Chemical Structure
    PP2 Chemical Structure
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  • 1/16

    PP2 purchased from MedChemExpress. Usage Cited in: FASEB J. 2020 Aug;34(8):10443-10461. [Abstract]

    Customer Validation
     Cells are pretreated with PP2 (10 μM) for 24 hours and further treated with MMS, and GAPDH nuclear translocation is visualized by confocal microscopy. The immunofluorescence staining results directly show that inhibiting Src activity by PP2 decreases GAPDH nuclear distribution in response to MMS.

  • 1/16

    PP2 purchased from MedChemExpress. Usage Cited in: Cancer Sci. 2018 May;109(5):1648-1659. [Abstract]

    Customer Validation
     Cells are treated with vehicle (0.1% DMSO) or PP2 (2.5 μM and 5 μM) for 48 h. Cell lysates are harvested. Total and phosphorylated c-Src are detected by western blotting.

  • 1/16

    PP2 purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2018 Aug;22(8):3768-3781. [Abstract]

    Customer Validation
     Prostate cancer cells are grown and treated with different concentrations of the Src inhibitor PP2 for 2 h and subjected to Western blot analysis. The data show that the inhibition of Src dose dependently decreases levels of p-Src527 but not p-Src426.

  • 1/16

    PP2 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150. [Abstract]

    Customer Validation
     MCF-7 cells are pretreated with the indicated chemical inhibitors for 30min, followed by 15 min treatment with RA (20 μM) + EPA (80 μM).Cell extracts are prepared and subjected to western blotting analysis.

  • 1/16

    PP2 purchased from MedChemExpress. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73. [Abstract]

    Customer Validation
     To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

  • PP2