IL3RA - interleukin 3 receptor subunit alpha Gene

Also Known as IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3563

About IL3RA

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,336,785-1,382,689 (from NCBI)

This gene has 3 transcripts (splice variants), 593 orthologues and 23 paralogues. Ubiquitous expression in lung (RPKM 8.7), lymph node (RPKM 8.6) and 24 other tissues.

Summary

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

IL3RA Products (2)

mRNA	Protein	Name
NM_001267713.2	NP_001254642.1	interleukin-3 receptor subunit alpha isoform 2 precursor
NM_002183.4	NP_002174.1	interleukin-3 receptor subunit alpha isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-3 receptor activity	IDA IDA: Inferred from direct assay	29374162	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29374162	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-3-mediated signaling pathway	IDA IDA: Inferred from direct assay	8649415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL3RA Protein Structure

IL6Ra-bind

0
100
200
300
378 a.a.

Protein Preferred Names	Protein Names
interleukin-3 receptor subunit alpha	CD123 antigen

IL3RA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL3RA	P26951	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
Intra	IL3RA	P26951	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	IL3RA	P26951	PAQR5	Homo sapiens	Q9NXK6	Validated Y2H	32296183
Intra	IL3RA	P26951	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	IL3RA	P26951	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	IL3RA	P26951	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	IL3RA	P26951	TMEM254	Homo sapiens	Q8TBM7	Validated Y2H	32296183
Intra	IL3RA	P26951	TUSC5	Homo sapiens	A5PKU2	Validated Y2H	32296183
Intra	IL3RA	P26951	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	IL3RA	P26951	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	IL3RA	P26951	SYS1	Homo sapiens	Q8N2H4	Validated Y2H	32296183
Intra	IL3RA	P26951	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
Intra	IL3RA	P26951	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL3RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70468	IL-3R alpha/CD123 Protein, Human (HEK293, His)	P26951-1 (T19-R305)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72349	IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P26951-1 (T19-R305)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700747	IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi)	P26951-1 (T19-R305)	≥ 95%, as determined by reducing SDS-PAGE.

IL3RA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811037	CD123 Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P81713	CD123 Antibody (YA1458)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Diphtheria	Corynebacterium Infections Corynebacterium Infection Diphtherial Infection Infection Due To Corynebacterium Diphtheriae
Hairy Cell Leukemia	Hcl-V Hairy Cell Leukemia Variant Hairy Cell Leukaemia Variant Hcl Leukemic Reticuloendotheliosis Leukemic Reticuloendotheliosis Variant Prolymphocytic Variant Of Hcl Prolymphocytic Variant Of Hairy Cell Leukemia Leukemia Hairy Cell Leukemia, Hairy Cell Leukaemic Reticuloendotheliosis Lre - [Leukemic Reticuloendotheliosis] Hairy-Cell Leukaemia, Nos Hcl - [Hairy Cell Leukaemia] Hairy-Cell Leukaemia Without Mention Of Remission
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Pulmonary Alveolar Proteinosis
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Acute Basophilic Leukemia
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Refractory Hairy Cell Leukemia
Amoxicillin Allergy
Oxirane Allergy	Ethylene Oxide Allergy Eto Allergy
Capillary Disease	Disease Of Capillaries
Refractory Hematologic Cancer	Refractory Hematologic Malignancy
Capillary Leak Syndrome	Systemic Capillary Leak Syndrome Clarkson Disease Capillary Leak Syndrome With Monoclonal Gammopathy Scls Periodic Systemic Capillary Leak Syndrome Capillary Hyperpermeability Syndrome Idiopathic Capillary Leak Syndrome
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Diclofenac Allergy	Voltaren Allergy
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Chlorhexidine Allergy
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Pancytopenia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991282	KHK2823	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06764	IL3RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174605	Human IL3RA mRNA		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991699	Lixarkitug	Inhibitor	99%	Unkown
HY-P990451	Anti-IL-3Ra/CD123 Antibody (SNG-CD123A)	Inhibitor	95.01%	Unkown
HY-P992032	TPP-9476	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL3RA	MGD	MGI:96553
Canis familiaris	IL3RA	VGNC	VGNC:54959
Rattus norvegicus	IL3RA	RGD	RGD:628728
Bos taurus	IL3RA	VGNC	VGNC:106780