P7-2104
Based on 1 Customer Validation
P7-2104 is a blood-brain barrier-permeable, selective PDE7A inhibitor with an IC50 of 31 nM. P7-2104 shows selectivity for hERG channels and most CYP450 subtypes. P7-2104 can be used for PDE7-targeted PET neuroimaging studies and research related to neurodegenerative diseases, when labeled with 11C or 18F.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 460346-02-5
- Formula: C14H17ClN2O2
- Molecular Weight:280.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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PDE7A 31 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.01 μM
Compound: 7
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Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cells
Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cells
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[PMID: 15324877] |
P7-2104 does not inhibit the hERG channel (IC50 > 100 μM), weakly inhibits CYP1A2 (IC50 = 4.4 μM), and does not significantly interact with other CYP450 isoforms (IC50 ≥ 10 μM)[1].
P7-2104 has free plasma fractions of ~2.8% in mouse, ~2.2% in rat, and ~1.4% in human plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Plasma Concentration | Brain Concentration |
|---|---|---|---|---|
| Rat[1] | 1 mg/kg | i.v. | 712.49 (5 min) ng/mL | 3316.17 (5 min) ng/g |
Chemical Information
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CAS No. 460346-02-5
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Appearance Solid
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Molecular Weight 280.75
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Formula C14H17ClN2O2
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Color White to off-white
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SMILES
O=C(N1)NC2=C(C31CCCCC3)C(OC)=CC=C2Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5.83 mg/mL (20.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5619 mL | 17.8094 mL | 35.6189 mL | 89.0472 mL |
| 5 mM | 0.7124 mL | 3.5619 mL | 7.1238 mL | 17.8094 mL | |
| 10 mM | 0.3562 mL | 1.7809 mL | 3.5619 mL | 8.9047 mL | |
| 15 mM | 0.2375 mL | 1.1873 mL | 2.3746 mL | 5.9365 mL | |
| 20 mM | 0.1781 mL | 0.8905 mL | 1.7809 mL | 4.4524 mL |
P7-2104 Related Classifications
HY-W074537 Related Classifications
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