Avermectin A1a
Avermectin A1a is a potent and broad-spectrum antiparasitic agent. Avermectin A1a targets nematodes and arthropods by binding to their glutamate-gated chloride channels to block nerve signal transmission and induce paralysis. Avermectin A1a can be used for the study of parasitic infection.
For research use only. We do not sell to patients.
- CAS No.: 65195-51-9
- Formula: C49H74O14
- Molecular Weight:887.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 65195-51-9
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Molecular Weight 887.10
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Formula C49H74O14
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SMILES
O[C@@H]1[C@H](C[C@@]([H])(O[C@H]1C)O[C@H]2[C@@H](O[C@]([H])(C[C@@H]2OC)O[C@H](/C(C)=C/C[C@]3(O[C@]4(CC(C3)OC5=O)C=C[C@@H]([C@]([H])(O4)[C@@H](C)CC)C)[H])[C@H](/C=C/C=C6[C@@]7([C@]([H])(OC/6)[C@@H](C(C)=C[C@]75[H])OC)O)C)C)OC
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Structure Classification
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Initial Source
Streptomyces avermitilis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Avermectin A1a Related Classifications
HY-W783593 Related Classifications
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