MS6178
MS6178 is a MS5105-based CFTR deubiquitinase-targeted chimera (DUBTAC) that recruits OTUB1 to stabilize ΔF508-CFTR mutant protein in a concentration- and time-dependent manner, with an OTUB1-dependent effect and no impact on CFTR mRNA level. MS6178 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 3060520-53-5
- Formula: C47H53F2N7O7S
- Molecular Weight:898.03
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MS6178 (0.5-10 µM; 0-24 h) effectively stabilizes the ΔF508-CFTR mutant protein in CFBE41o-4.7 ΔF508-CFTR cells in a concentration-, time-, OTUB1-, and CFTR-dependent manner (30-fold increase at 10 μM for 24 h)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3060520-53-5
-
Molecular Weight 898.03
-
Formula C47H53F2N7O7S
-
SMILES
O=C(NC1=NC(C2=CC=CC(C(NCCCCCCC(NCCC3=CC=C(N4CCN(C(/C=C/CN(C)C)=O)CC4=O)S3)=O)=O)=C2)=C(C)C=C1)C5(CC5)C6=CC7=C(OC(F)(F)O7)C=C6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz