Isoformononetin-d3
Based on 1 Customer Validation
Isoformononetin-d3 is the deuterium labeled Isoformononetin (HY-N7501). Isoformononetin is an analog of Daidzein (HY-N0019) and has immunoprotective effects. Isoformononetin inhibits the differentiation of Th17 and B-cells lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.
For research use only. We do not sell to patients.
- Purity: 98.64%
- Formula: C16H9D3O4
- Molecular Weight:271.28
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
Unlabeled Cas 486-63-5
-
Appearance Solid
-
Molecular Weight 271.28
-
Formula C16H9D3O4
-
Color Off-white to light yellow
-
SMILES
O=C1C2=CC=C(OC([2H])([2H])[2H])C=C2OC=C1C3=CC=C(O)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL (921.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Mansoori MN, et al. Methoxyisoflavones formononetin and isoformononetin inhibit the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. Menopause. 2016 May;23(5):565-76. [Content Brief]
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6862 mL | 18.4311 mL | 36.8623 mL | 92.1557 mL |
| 5 mM | 0.7372 mL | 3.6862 mL | 7.3725 mL | 18.4311 mL | |
| 10 mM | 0.3686 mL | 1.8431 mL | 3.6862 mL | 9.2156 mL | |
| 15 mM | 0.2457 mL | 1.2287 mL | 2.4575 mL | 6.1437 mL | |
| 20 mM | 0.1843 mL | 0.9216 mL | 1.8431 mL | 4.6078 mL | |
| 25 mM | 0.1474 mL | 0.7372 mL | 1.4745 mL | 3.6862 mL | |
| 30 mM | 0.1229 mL | 0.6144 mL | 1.2287 mL | 3.0719 mL | |
| 40 mM | 0.0922 mL | 0.4608 mL | 0.9216 mL | 2.3039 mL | |
| 50 mM | 0.0737 mL | 0.3686 mL | 0.7372 mL | 1.8431 mL | |
| 60 mM | 0.0614 mL | 0.3072 mL | 0.6144 mL | 1.5359 mL | |
| 80 mM | 0.0461 mL | 0.2304 mL | 0.4608 mL | 1.1519 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3686 mL | 0.9216 mL |
Powered by Bioz