Cat. No.: HY-149873

Anticancer agent 126

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Based on 1 Customer Validation

Anticancer agent 126 (compound 12) is a WDR5 inhibitor with anticancer effects. Anticancer agent 126 disrupts WDR5-MYC interaction in cells and reduce MYC target gene expression.

For research use only. We do not sell to patients.

Purity: 98.05%
CAS No.: 3033748-20-5
Formula: C₂₅H₁₈F₃N₃O₄S
Molecular Weight:513.49

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Anticancer agent 126 Chemical Structure

CAS No.: 3033748-20-5

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Anticancer agent 126 (compound 12) is a WDR5 inhibitor with anticancer effects. Anticancer agent 126 disrupts WDR5-MYC interaction in cells and reduce MYC target gene expression^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
COR-L279	GI₅₀	4.2 μM Compound: 12	Antiproliferative activity against human COR-L279 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human COR-L279 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
Daudi	GI₅₀	15.4 μM Compound: 12	Antiproliferative activity against human Daudi cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human Daudi cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
HL-60	GI₅₀	4.6 μM Compound: 12	Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
NB-4	GI₅₀	7.1 μM Compound: 12	Antiproliferative activity against human NB4 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human NB4 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
NCI-H1650	GI₅₀	22.6 μM Compound: 12	Antiproliferative activity against human NCI-H1650 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human NCI-H1650 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
NCI-H520	GI₅₀	9.4 μM Compound: 12	Antiproliferative activity against human NCI-H520 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human NCI-H520 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
Ramos	GI₅₀	4.3 μM Compound: 12	Antiproliferative activity against human Ramos cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human Ramos cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]
SHP77	GI₅₀	16.6 μM Compound: 12	Antiproliferative activity against human SHP77 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay Antiproliferative activity against human SHP77 cells assessed as cell growth inhibition measured after 72 hrs by CellTier-Glo assay	[PMID: 37307526]

Chemical Information

CAS No. 3033748-20-5
Appearance Solid
Molecular Weight 513.49
Formula C₂₅H₁₈F₃N₃O₄S
Color White to off-white
SMILES

FC1=C(C(F)=CC(C2=CC(S(=O)(F)=O)=CC=C2)=C1)CNC(C3=NN(C(C)=CC3=O)C4=CC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 6.67 mg/mL (12.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9475 mL

9.7373 mL

19.4746 mL

5 mM

0.3895 mL

1.9475 mL

3.8949 mL

10 mM

0.1947 mL

0.9737 mL

1.9475 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.67 mg/mL (1.30 mM); Clear solution

This protocol yields a clear solution of ≥ 0.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (6.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jian Ding, et al. Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J Med Chem. 2023 Jun 22;66(12):8310-8323. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9475 mL	9.7373 mL	19.4746 mL	48.6864 mL
	5 mM	0.3895 mL	1.9475 mL	3.8949 mL	9.7373 mL
	10 mM	0.1947 mL	0.9737 mL	1.9475 mL	4.8686 mL

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Anticancer agent 126

Epigenetics Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Anticancer agent 126

Epigenetics Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Anticancer agent 126 Related Classifications

HY-149873 Related Classifications