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Cat. No.: HY-139165

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AT-9010

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication.

For research use only. We do not sell to patients.

CAS No.: 1261253-79-5
Formula: C₁₁H₁₇FN₅O₁₃P₃
Molecular Weight:539.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AT-9010 Chemical Structure

CAS No.: 1261253-79-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication^[1].

IC₅₀ & Target

NiRAN^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>100 μM Compound: 2-TP	Inhibition of RNA polymerase 2 in human HeLa cell nuclear extract assessed as reduction in RNA transcription by polyacrylamide gel electrophoresis method Inhibition of RNA polymerase 2 in human HeLa cell nuclear extract assessed as reduction in RNA transcription by polyacrylamide gel electrophoresis method	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 6	Cytotoxicity against human HuH7 cells Cytotoxicity against human HuH7 cells	[PMID: 21050754]

In Vitro

Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1261253-79-5
Molecular Weight 539.20
Formula C₁₁H₁₇FN₅O₁₃P₃
SMILES

O[C@H]1[C@](F)(C)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COP(O)(OP(OP(O)(O)=O)(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Cell

A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. [Abstract]

2022 Nov 10;185(23):4347-4360.e17. PMID: 36335936

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Atea Pharmaceuticals Announces Publication of Preclinical Data Highlighting Potent Activity of AT-527 Against SARS-CoV-2. BOSTON, Feb. 08, 2021. Atea Pharmaceuticals, Inc.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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AT-9010

Publications Citing Use of MedChemExpress (MCE) AT-9010