CAY10581
CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM.
For research use only. We do not sell to patients.
- CAS No.: 1018340-07-2
- Formula: C22H21NO4
- Molecular Weight:363.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IDO 55 nM (IC50) |
CAY10581 (100 nM; 24 h) abrogates the growth inhibition by IFN-gamma in MSCs[1].
CAY10581 (compound 36) demonstrates minimal impact on T-REx cells viability at 100 μM after 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mesenchymal stem cells (MSCs)
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Concentration:100 nM
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Incubation Time:24 h post-treatment
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Result:Abrogated the growth inhibition by IFN-gamma (50 ng/ml) in MSCs.
Chemical Information
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CAS No. 1018340-07-2
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Molecular Weight 363.41
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Formula C22H21NO4
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SMILES
O=C1C2=C(C(C3=C1C=CC=C3)=O)[C@@H]([C@@H](C(C)(O2)C)O)NCC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sanjeev Kumar, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. [Content Brief]
[2]. Siddaraju V Boregowda, et al. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells. EBioMedicine. 2015 Dec 24;4:62-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAY10581 Related Classifications
HY-113568 Related Classifications
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