GALA-Cys
Based on 1 Customer Validation
GALA-Cys is a chemically modified GALA peptide (HY-P5423) that retains GALA functions while acquiring strong covalent conjugation capability. GALA-Cys undergoes pH-driven reversible secondary structure transition, rearranges into an amphipathic α-helix, self-oligomerizes, penetrates lipid membranes to form pores, and disrupts lipid bilayers, thereby enabling endosomal escape and cytosolic cargo delivery. GALA-Cys can be conjugated with lipid DPTE for integration into liposomes, self-assembles into a tilted monolayer on gold surfaces, and serves as a pH-responsive coating for particle surface functionalization. GALA-Cys is applicable to studies related to targeted cargo delivery.
For research use only. We do not sell to patients.
- Formula: C141H223N35O46S
- Molecular Weight:3176.55
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GALA-Cys is covalently linked to the thiol-containing phospholipid DPTE via pyridyl disulfide click chemistry to form the lipopeptide DPTE-GALA. Similar to conventional phospholipids, this lipopeptide can be quantitatively and controllably incorporated into lipid bilayers during liposome preparation[1].
GALA-Cys can utilize the terminal cysteine thiol group to form a stable Au-S covalent bond directly with the gold surface, thereby forming a self-assembled monolayer on the gold substrate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 3176.55
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Formula C141H223N35O46S
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Color White to off-white
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Sequence
Ac-Trp-Glu-Ala-Ala-Leu-Ala-Glu-Ala-Leu-Ala-Glu-Ala-Leu-Ala-Glu-His-Leu-Ala-Glu-Ala-Leu-Ala-Glu-Ala-Leu-Glu-Ala-Leu-Ala-Ala-Cys-NH2
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Sequence Shortening
Ac-WEAALAEALAEALAEHLAEALAEALEALAAC-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
[1].
de la Fuente-Herreruela D, et al. Lipid-peptide bioconjugation through pyridyl disulfide reaction chemistry and its application in cell targeting and drug delivery. J Nanobiotechnology. 2019 Jun 21;17(1):77.
[Content Brief]
[2]. Baio JE, et al. Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces. Chem Commun (Camb). 2015;51(2):273-275. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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