GPR39 - G protein-coupled receptor 39 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2863

About GPR39

Cytogenetic location: 2q21.2 Genomic coordinates (GRCh38): 2:132,416,805-132,646,582 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 15 paralogues. Broad expression in brain (RPKM 4.2), colon (RPKM 3.1) and 19 other tissues.

Summary

This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]

GPR39 Products (1)

mRNA Protein Name
NM_001508.3 NP_001499.1 G-protein coupled receptor 39

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26365466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR39 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (59 - 344)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 39

GPR39 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR39 O43194 HTR1A Homo sapiens P08908
Anti Tag CoIP
26365466
Intra
GPR39 O43194 HTR1A Homo sapiens P08908
IF
26365466
Intra
GPR39 O43194 HTR1A Homo sapiens P08908
FRET
26365466
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Benign Essential Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113238A Lithocholic acid 3-sulfate disodium 99.93% Unkown
HY-103007 TC-G-1008 Agonist 99.36% Unkown
HY-137255 Taurolithocholic acid 3-sulfate disodium Agonist 99.9% Unkown
HY-108699 TM-N1324 Agonist 99.90% Unkown
HY-W587430 Glycolithocholic acid 3-sulfate disodium 99.73% Unkown
HY-P1421 Obestatin(human) 99.74% Unkown
HY-182367 TMN-OMe Agonist / Unkown
HY-P1306 Obestatin(rat) 98.73% Unkown
HY-P1306A Obestatin(rat) TFA / Unkown
HY-RS05711 GPR39 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17549 Gpr39 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24008 Gpr39 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR39 VGNC VGNC:41434
Mus musculus GPR39 MGD MGI:1918361
Rattus norvegicus GPR39 RGD RGD:1306745
Others GPR39 NCBI