ARHGDIA - Rho GDP dissociation inhibitor alpha Gene

Also Known as GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 396

About ARHGDIA

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,867,721-81,871,337 (from NCBI)

This gene has 17 transcripts (splice variants), 278 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 69.2), fat (RPKM 67.4) and 25 other tissues.

Summary

This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ARHGDIA Products (7)

mRNA	Protein	Name
NM_001185077.3	NP_001172006.1	rho GDP-dissociation inhibitor 1 isoform a
NM_001185078.3	NP_001172007.1	rho GDP-dissociation inhibitor 1 isoform b
NM_001301240.2	NP_001288169.1	rho GDP-dissociation inhibitor 1 isoform c
NM_001301241.2	NP_001288170.1	rho GDP-dissociation inhibitor 1 isoform c
NM_001301242.2	NP_001288171.1	rho GDP-dissociation inhibitor 1 isoform d
NM_001301243.2	NP_001288172.1	rho GDP-dissociation inhibitor 1 isoform e
NM_004309.6	NP_004300.1	rho GDP-dissociation inhibitor 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10489445	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	8262133	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGDIA Protein Structure

Rho_GDI

0
100
204 a.a.

Protein Preferred Names	Protein Names
rho GDP-dissociation inhibitor 1	GDP-dissociation inhibitor, aplysia RAS-related 1

ARHGDIA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARHGDIA	P52565	RAC1	Homo sapiens	P63000	Anti Bait CoIP	17353931
Intra	ARHGDIA	P52565	RHOA	Homo sapiens	P61586	Validated Y2H	25416956
Intra	ARHGDIA	P52565	RHOA	Homo sapiens	P61586	X-Ray Diffraction	10489445
Intra	ARHGDIA	P52565	RHOA	Homo sapiens	P61586	Anti Bait CoIP	17353931
Intra	ARHGDIA	P52565	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	ARHGDIA	P52565	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	ARHGDIA	P52565	CDC42	Homo sapiens	P60953	Y2H Pooling	20936779
Intra	ARHGDIA	P52565	CDC42	Homo sapiens	P60953	Y2H	21900206
Intra	ARHGDIA	P52565	CDC42	Homo sapiens	P60953	Anti Bait CoIP	17353931

Cross: Cross-species interaction Intra: Intraspecies interaction

ARHGDIA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82118	RhoGDI Antibody (YA1863)	WB	Human, Mouse, Rat
HY-P82118A	RhoGDI Antibody (YA1863)(PBS only)	WB	Human, Mouse, Rat
HY-P84383	RhoGDI Antibody (YA4080)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P84383A	RhoGDI Antibody (YA4080)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 8	NPHS8 Nephrotic Syndrome Type 8 Nephrotic Syndrome 8
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Diffuse Mesangial Sclerosis	Familial Mesangial Sclerosis Mesangial Sclerosis, Diffuse Dms Diffuse Isolated Mesangial Sclerosis Isolated Diffuse Mesangial Sclerosis Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis
Osteogenesis Imperfecta, Type Xxi	OI21 Osteogenesis Imperfecta Type 21 Osteogenesis Imperfecta, Type 21 Osteogenesis Imperfecta Type Xxi Osteogenesis Imperfecta 21
Articulation Disorder	Phonological Disorder Articulation Disorders Articulation Impairment Speech Sound Disorders
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Speech Disorder	Speech Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180371	NF-115	Inducer	/	Unkown
HY-RS00943	ARHGDIA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARHGDIA	VGNC	VGNC:26101
Rattus norvegicus	ARHGDIA	RGD	RGD:1359547
Macaca mulatta	ARHGDIA	VGNC	VGNC:70010
Canis familiaris	ARHGDIA	VGNC	VGNC:38069
Mus musculus	ARHGDIA	MGD	MGI:2178103
Others	ARHGDIA	NCBI