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MGST2 - microsomal glutathione S-transferase 2 Gene

Also Known as GST2; MGST-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4258

About MGST2

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,665,819-139,754,618 (from NCBI)

This gene has 7 transcripts (splice variants), 158 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 15.9), small intestine (RPKM 13.0) and 25 other tissues.

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

MGST2 Products (4)

mRNA	Protein	Name
NM_001204366.2	NP_001191295.1	microsomal glutathione S-transferase 2 isoform 1 precursor
NM_001204367.2	NP_001191296.1	microsomal glutathione S-transferase 2 isoform 2
NM_001204368.2	NP_001191297.1	microsomal glutathione S-transferase 2 isoform 3 precursor
NM_002413.5	NP_002404.1	microsomal glutathione S-transferase 2 isoform 1 precursor

MGST2 Protein Structure

MAPEG

0
100
147 a.a.

Protein Preferred Names	Protein Names
microsomal glutathione S-transferase 2	glutathione peroxidase MGST2

MGST2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MGST2	Q99735	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	MGST2	Q99735	TMEM207	Homo sapiens	Q6UWW9	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	TMEM207	Homo sapiens	Q6UWW9	Y2H Array	32296183
Intra	MGST2	Q99735	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	MGST2	Q99735	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	MGST2	Q99735	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	MGST2	Q99735	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	CLEC14A	Homo sapiens	Q86T13	Y2H Array	32296183
Intra	MGST2	Q99735	CLEC14A	Homo sapiens	Q86T13	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	BCL2L10	Homo sapiens	Q9HD36	Validated Y2H	32296183
Intra	MGST2	Q99735	SGCB	Homo sapiens	Q16585	Y2H Array	32296183
Intra	MGST2	Q99735	SGCB	Homo sapiens	Q16585	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	MGST2	Q99735	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	MGST2	Q99735	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	MGST2	Q99735	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	MGST2	Q99735	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	MGST2	Q99735	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Persistent Mild Asthma
Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1916	Coniferyl ferulate		98.73%	Unkown
HY-RS08417	MGST2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22638	Mgst2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29153	Mgst2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MGST2	VGNC	VGNC:68252
Mus musculus	MGST2	MGD	MGI:2448481
Macaca mulatta	MGST2	VGNC	VGNC:74719
Rattus norvegicus	MGST2	RGD	RGD:1311218
Canis familiaris	MGST2	VGNC	VGNC:54328
Bos taurus	MGST2	VGNC	VGNC:31452
Others	MGST2	NCBI