Lipid 14
Based on 1 Customer Validation
Lipid 14 is an ionizable amino lipid. Lipid 14 delivers mRNA into target cells, significantly enhancing the in vivo expression efficiency and immunogenicity of mRNA. Lipid 14 can be used to synthesize lipid nanoparticles (LNPs). Lipid 14 can be used for studies of SARS-CoV-2 and Yersinia pestis.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2430034-05-0
- Formula: C56H110N2O6
- Molecular Weight:907.48
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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Lipid Compound Library
HY-L043
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Antibacterial Compound Library
HY-L049
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Liposome Library
HY-L214
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Ionizable Lipid Compound Library
HY-L251
Biological Activity
Lipid 14 (5 μg mRNA-LNP; i.m.; single or triple dose) encapsulated SP-cp-caf1-hFc mRNA induces highly efficient anti-F1 antibodies and completely protects mice against lethal Y. pestis attacks in a single immunization[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2430034-05-0
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Appearance Oil
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Molecular Weight 907.48
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Formula C56H110N2O6
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Color Colorless to light yellow
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SMILES
O=C(CCCN(C)C)OCCN(CCCCCCCCOC(C(CCCCCCCC)CCCCCC)=O)CCCCCCCCOC(C(CCCCCCCC)CCCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (110.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Elia U, et al. Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles. ACS Nano. 2021 Jun 22;15(6):9627-9637. [Content Brief]
[2]. Kon E, et al. A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium. Sci Adv. 2023 Mar 10;9(10):eadg1036. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1020 mL | 5.5098 mL | 11.0195 mL | 27.5488 mL |
| 5 mM | 0.2204 mL | 1.1020 mL | 2.2039 mL | 5.5098 mL | |
| 10 mM | 0.1102 mL | 0.5510 mL | 1.1020 mL | 2.7549 mL | |
| 15 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8366 mL | |
| 20 mM | 0.0551 mL | 0.2755 mL | 0.5510 mL | 1.3774 mL | |
| 25 mM | 0.0441 mL | 0.2204 mL | 0.4408 mL | 1.1020 mL | |
| 30 mM | 0.0367 mL | 0.1837 mL | 0.3673 mL | 0.9183 mL | |
| 40 mM | 0.0275 mL | 0.1377 mL | 0.2755 mL | 0.6887 mL | |
| 50 mM | 0.0220 mL | 0.1102 mL | 0.2204 mL | 0.5510 mL | |
| 60 mM | 0.0184 mL | 0.0918 mL | 0.1837 mL | 0.4591 mL | |
| 80 mM | 0.0138 mL | 0.0689 mL | 0.1377 mL | 0.3444 mL | |
| 100 mM | 0.0110 mL | 0.0551 mL | 0.1102 mL | 0.2755 mL |
Lipid 14 Related Classifications
HY-153377 Related Classifications
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