MEDI-8852
Based on 1 Customer Validation
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
For research use only. We do not sell to patients.
- Purity: 97.23%
- Molecular Weight:146.38 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Virus
influenza A virus hemagglutinin HA
MEDI-8852 (< 50 μg/mL) potently neutralizes a broad panel of group I and group II pandemic-potential influenza A viruses in MDCK cells, with all 50% inhibitory concentrations (IC50 values) below 50 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MEDI-8852 (1-10 mg/kg; i.p.; single dose; 24 hours pre-challenge) confers dose-dependent prophylactic efficacy against H5N1 influenza in BALB/c mice, with 10 mg/kg providing 100% survival and no significant weight loss[1].
MEDI-8852 (1-10 mg/kg; i.p.; single dose; 24, 48, or 72 hours post-infection) confers time- and dose-dependent therapeutic efficacy against H7N9 influenza in BALB/c mice, with 10 mg/kg administered at 24 hours post-infection providing 90% survival[1].
MEDI-8852 (1-10 mg/kg; i.p.; single dose; 24, 48, or 72 hours post-infection) confers time- and dose-dependent therapeutic efficacy against H5N1 influenza in BALB/c mice, with 10 mg/kg administered at 48 or 72 hours post-infection providing 100% survival and no significant weight loss[1].
MEDI-8852 (25 mg/kg; i.p.; single dose; 24 or 72 hours post-infection) provides therapeutic efficacy against H7N9 influenza in ferrets, with 25 mg/kg administered at 24 hours post-infection limiting weight loss to <10%[1].
MEDI-8852 (6.25-25 mg/kg; i.v.; single dose; 72 hours post-infection) provides dose-dependent therapeutic efficacy against H5N1 influenza in ferrets when administered at 72 hours post-infection, with 12.5 mg/kg providing 86% survival[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (6-8 weeks old; intranasal challenge with influenza A/Anhui/01/2013 [H7N9] virus)[1]
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Dosage:0.2-10 mg/kg
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Administration:i.p.; single dose; 24 hours pre-challenge
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Result:Achieved 100% survival, <5% weight loss, and significant reductions in lung viral titers on days 3 and 5 post-infection at 10 mg/kg.
Achieved 90% survival with <10% weight loss at 1 mg/kg.
Achieved 20% survival and 25% weight loss at 0.2 mg/kg.
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Animal Model:BALB/c (6-8 weeks old; intranasal challenge with influenza A/Vietnam/1203/2004 [H5N1] virus)[1]
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Dosage:1-10 mg/kg (24 hours post-infection); 1-10 mg/kg (48 hours post-infection); 1-10 mg/kg (72 hours post-infection)
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Administration:i.p.; single dose; 24, 48, or 72 hours post-infection
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Result:Achieved 90% survival with no significant weight loss at 10 mg/kg administered 24 hours post-infection.
Achieved 100% survival with no significant weight loss at 10 mg/kg administered 48 or 72 hours post-infection.
Achieved 100% survival with 10-20% weight loss at 1 mg/kg administered 24 hours post-infection.
Achieved 80% survival with 10-20% weight loss at 1 mg/kg administered 48 hours post-infection.
Achieved 40% survival with 10-20% weight loss at 1 mg/kg administered 72 hours post-infection.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 146.38 kDa
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Color Colorless to light yellow
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SMILES
[MEDI-8852]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MEDI-8852 Related Classifications
HY-P991446 Related Classifications
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