SP11
Based on 1 Customer Validation
SP11 is a mitochondrial fission protein 1 (Fis1) inhibitor with an IC50 of 9.4 μM. SP11 binds only to activated Fis1 by engaging Cys41. SP11 preserves mitochondrial integrity and function during oxidative stress, inhibits hydrogen peroxide-induced mitochondrial ROS production, mitochondrial fragmentation, and Drp1 mitochondrial translocation. SP11 can be used for the research of parkinson’s disease.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 2629218-24-0
- Formula: C18H19ClN2OS
- Molecular Weight:346.87
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SP11 potently and specifically inhibits to the Cys41 residue of activated Fis1Thr34Asp, with an IC50 of 9.4 μM[1].
SP11 (250 nM; 24 h) prevents hydrogen peroxide-induced mitochondrial ROS production, fragmentation and increased Drp1 translocation to the mitochondria in HK-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HK-2 human renal proximal tubule epithelial cells
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Concentration:250 nM (pre-incubation, then co-treated with 100 μM hydrogen peroxide)
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Incubation Time:30 min (pre-incubation); 24 h (co-treatment)
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Result:Significantly reduced hydrogen peroxide-induced Drp1 recruitment to mitochondria.
Lowered Drp1/VDAC levels to near vehicle control levels.
Chemical Information
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CAS No. 2629218-24-0
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Appearance Oil
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Molecular Weight 346.87
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Formula C18H19ClN2OS
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Color Light yellow to yellow
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SMILES
CN(C(CCl)=O)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (72.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8829 mL | 14.4146 mL | 28.8292 mL | 72.0731 mL |
| 5 mM | 0.5766 mL | 2.8829 mL | 5.7658 mL | 14.4146 mL | |
| 10 mM | 0.2883 mL | 1.4415 mL | 2.8829 mL | 7.2073 mL | |
| 15 mM | 0.1922 mL | 0.9610 mL | 1.9219 mL | 4.8049 mL | |
| 20 mM | 0.1441 mL | 0.7207 mL | 1.4415 mL | 3.6037 mL | |
| 25 mM | 0.1153 mL | 0.5766 mL | 1.1532 mL | 2.8829 mL | |
| 30 mM | 0.0961 mL | 0.4805 mL | 0.9610 mL | 2.4024 mL | |
| 40 mM | 0.0721 mL | 0.3604 mL | 0.7207 mL | 1.8018 mL | |
| 50 mM | 0.0577 mL | 0.2883 mL | 0.5766 mL | 1.4415 mL | |
| 60 mM | 0.0480 mL | 0.2402 mL | 0.4805 mL | 1.2012 mL |
SP11 Related Classifications
HY-172942 Related Classifications
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