XL44
Based on 1 Customer Validation
XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 2637949-91-6
- Formula: C23H17FN2O3
- Molecular Weight:388.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Covalent Screening Library
HY-L036
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
XL44 (20 μM, 4-24 h, lysates from RPMI 8226 cells) induces apoptosis in an hRpn13-dependent manner and reduces hRpn13Pru levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Lysates from RPMI 8226 cells.
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Concentration:20 μM.
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Incubation Time:4-24 h.
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Result:Caused a reduction in hRpn13Pru levels in RPMI 8226 WT cells.
Chemical Information
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CAS No. 2637949-91-6
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Appearance Solid
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Molecular Weight 388.39
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Formula C23H17FN2O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(OC)C=C1)NC2=CC=CC(/C=C3C(NC4=C\3C=C(F)C=C4)=O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (51.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5747 mL | 12.8737 mL | 25.7473 mL | 64.3683 mL |
| 5 mM | 0.5149 mL | 2.5747 mL | 5.1495 mL | 12.8737 mL | |
| 10 mM | 0.2575 mL | 1.2874 mL | 2.5747 mL | 6.4368 mL | |
| 15 mM | 0.1716 mL | 0.8582 mL | 1.7165 mL | 4.2912 mL | |
| 20 mM | 0.1287 mL | 0.6437 mL | 1.2874 mL | 3.2184 mL | |
| 25 mM | 0.1030 mL | 0.5149 mL | 1.0299 mL | 2.5747 mL | |
| 30 mM | 0.0858 mL | 0.4291 mL | 0.8582 mL | 2.1456 mL | |
| 40 mM | 0.0644 mL | 0.3218 mL | 0.6437 mL | 1.6092 mL | |
| 50 mM | 0.0515 mL | 0.2575 mL | 0.5149 mL | 1.2874 mL |
XL44 Related Classifications
HY-162393 Related Classifications
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