JAMI1001A

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JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms.

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JAMI1001A Chemical Structure

CAS No. : 1001019-46-0

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Description	JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms^[1].
In Vitro	JAMI1001A binds in the solvent accessible allosteric pocket that lies at the interface between AMPA receptor ligand-binding core dimers. JAMI1001A efficaciously blocks channel desensitization and slows deactivation of the flip and flop isoforms of AMPA receptor GluA2^[1]. A simple kinetic model suggests that JAMI1001A independently modulates both the protein rearrangements necessary for channel desensitization and its recovery from the desensitized state, and the protein rearrangements necessary for channel deactivation (closed-cleft stability or channel gating)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. JAMI1001A Related Antibodies
Molecular Weight	402.39
Formula	C₁₆H₁₇F₃N₄O₃S
CAS No.	1001019-46-0
SMILES	O=C(NC1=C(C(N)=O)C(CCCC2)=C2S1)CN3N=C(C(F)(F)F)C(CO)=C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Harms JE, et al. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology. 2013;64(1):45-52. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAMI1001A1001019-46-0iGluRIonotropic glutamate receptorsdeactivationdesensitizationchannelrearrangementisoformslearningmemoryInhibitorinhibitorinhibit

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JAMI1001A

JAMI1001A Related Antibodies

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