1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. JAMI1001A

JAMI1001A 

Cat. No.: HY-124906
Handling Instructions

JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms.

For research use only. We do not sell to patients.

JAMI1001A Chemical Structure

JAMI1001A Chemical Structure

CAS No. : 1001019-46-0

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Description

JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms[1].

In Vitro

JAMI1001A binds in the solvent accessible allosteric pocket that lies at the interface between AMPA receptor ligand-binding core dimers. JAMI1001A efficaciously blocks channel desensitization and slows deactivation of the flip and flop isoforms of AMPA receptor GluA2[1].
A simple kinetic model suggests that JAMI1001A independently modulates both the protein rearrangements necessary for channel desensitization and its recovery from the desensitized state, and the protein rearrangements necessary for channel deactivation (closed-cleft stability or channel gating)[1].

Molecular Weight

402.39

Formula

C₁₆H₁₇F₃N₄O₃S

CAS No.

1001019-46-0

SMILES

O=C(NC1=C(C(N)=O)C(CCCC2)=C2S1)CN3N=C(C(F)(F)F)C(CO)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JAMI1001AiGluRIonotropic glutamate receptorsdeactivationdesensitizationchannelrearrangementisoformslearningmemoryInhibitorinhibitorinhibit

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