1. Apoptosis Metabolic Enzyme/Protease
  2. Glutathione Peroxidase Ferroptosis
  3. JKE-1716

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.

For research use only. We do not sell to patients.

JKE-1716 Chemical Structure

JKE-1716 Chemical Structure

CAS No. : 2421118-05-8

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1 mg USD 170 In-stock
5 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

IC50 & Target

GPX4[1]; Ferroptosis[1]

In Vitro

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1].
JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LOX-IMVI cells
Concentration: 0~100 nΜ
Incubation Time: 72 hours
Result: Inhibited cell viability.
Molecular Weight

451.30

Formula

C20H20Cl2N4O4

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C/C([N+]([O-])=O)=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JKE-1716
Cat. No.:
HY-139001
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