1. Metabolic Enzyme/Protease
    Apoptosis
  2. Glutathione Peroxidase
    Ferroptosis
  3. JKE-1716

JKE-1716 

Cat. No.: HY-139001
Handling Instructions

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.

For research use only. We do not sell to patients.

JKE-1716 Chemical Structure

JKE-1716 Chemical Structure

CAS No. : 2421118-05-8

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Description

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

IC50 & Target

GPX4[1]; Ferroptosis[1]

In Vitro

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1].
JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LOX-IMVI cells
Concentration: 0~100 nΜ
Incubation Time: 72 hours
Result: Inhibited cell viability.
Molecular Weight

451.30

Formula

C₂₀H₂₀Cl₂N₄O₄

CAS No.
SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C/C([N+]([O-])=O)=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JKE-1716JKE1716JKE 1716Glutathione PeroxidaseFerroptosisLOX-IMVIPotentSelectiveNitrolicCovalenInhibitorinhibitorinhibit

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JKE-1716
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HY-139001
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