Copper Fluor-4
Based on 5 publication(s) in Google Scholar
Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10−13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission).
For research use only. We do not sell to patients.
- Purity: 95.11%
- CAS No.: 2365532-64-3
- Formula: C38H47F3N2O2S4
- Molecular Weight:749.05
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Copper Fluor-4
More
Biological Activity
Copper Fluor-4 (0.8 μM, 10 min) demonstrates localization of the copper in the soma region, which includes its localization in the perinuclear Golgi region in the PC-12-derived neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Copper Fluor-4 (10 µM, 3 h) can be used to assess labile Cu levels with a Kd value of 2.9×10−13 M for a 1:1 copper:probe stoichiometry that is well-matched to monitor labile Cu pools by reversible Cu binding without depleting the total Cu store in worms[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2365532-64-3
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Appearance Solid
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Molecular Weight 749.05
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Formula C38H47F3N2O2S4
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Color Brown to reddish brown
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SMILES
O=C1C=CC2=C(C3=C(C(F)(F)F)C=C(CN(CCSCCSCC)CCSCCSCC)C=C3)C4=C(C=C(N5CCCCC5)C=C4)OC2=C1
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Synonyms
CF4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Astrocytic FDX1 Contributes to Copper Dyshomeostasis-associated Synaptic Dysfunction in Depression and Is Modulated by Exercise. [Abstract]2026 Jun 15:e76088. PMID: 42294641 -
J Colloid Interface Sci
Copper peroxide/manganese dioxide nanoparticles crosslinked hyaluronan hydrogel for enhanced chemodynamic/photodynamic/photothermal therapy in breast cancer. [Abstract]2025 Sep 25;703(Pt 1):139121. PMID: 41037888 -
Ecotoxicol Environ Saf
2025 Sep 15:303:118923. PMID: 40850113 -
Int Immunopharmacol
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma. [Abstract]2026 May 15:177:116495. PMID: 41855775 -
Mol Med Rep
ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression. [Abstract]2026 Jul;34(1):202. PMID: 42169636
Solvent & Solubility
DMSO : 125 mg/mL (166.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Xiao T, et al. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 2018 Jul;14(7):655-663. [Content Brief]
[2]. Weishaupt AK, et al. Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans. Front Mol Biosci. 2024 Feb 8;11:1354627. [Content Brief]
[3]. Chakraborty K, et al. Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia. Metallomics. 2022 Apr 1;14(4):mfac005. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3350 mL | 6.6751 mL | 13.3502 mL | 33.3756 mL |
| 5 mM | 0.2670 mL | 1.3350 mL | 2.6700 mL | 6.6751 mL | |
| 10 mM | 0.1335 mL | 0.6675 mL | 1.3350 mL | 3.3376 mL | |
| 15 mM | 0.0890 mL | 0.4450 mL | 0.8900 mL | 2.2250 mL | |
| 20 mM | 0.0668 mL | 0.3338 mL | 0.6675 mL | 1.6688 mL | |
| 25 mM | 0.0534 mL | 0.2670 mL | 0.5340 mL | 1.3350 mL | |
| 30 mM | 0.0445 mL | 0.2225 mL | 0.4450 mL | 1.1125 mL | |
| 40 mM | 0.0334 mL | 0.1669 mL | 0.3338 mL | 0.8344 mL | |
| 50 mM | 0.0267 mL | 0.1335 mL | 0.2670 mL | 0.6675 mL | |
| 60 mM | 0.0223 mL | 0.1113 mL | 0.2225 mL | 0.5563 mL | |
| 80 mM | 0.0167 mL | 0.0834 mL | 0.1669 mL | 0.4172 mL | |
| 100 mM | 0.0134 mL | 0.0668 mL | 0.1335 mL | 0.3338 mL |
Copper Fluor-4 Related Classifications
HY-150086 Related Classifications
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